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Consolidated Statements of Stockholders' Equity (USD $)
In Thousands, except Share data, unless otherwise specified
Common Stock [Member]
In Treasury [Member]
Preferred Stock [Member]
Additional Paid-in Capital [Member]
Deficit Accumulated During Development Stage [Member]
Accumulated Other Comprehensive Loss [Member]
Total
Balance at Aug. 04, 1988 $ 0 $ 0 $ 0 $ 0 $ 0 $ 0 $ 0
Balance (in shares) at Aug. 04, 1988 0 0 0        
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Sale of common stock, net of expenses 137 3 0 29,911 0 0 30,051
Sale of common stock, net of expenses (in shares) 13,708,783 311,393 0        
Sale of preferred stock 0 0 24 1,741 0 0 1,765
Sale of preferred stock (in shares) 0 0 2,416,675        
Dividends paid on preferred stock 7 0 0 992 (1,499) 0 (500)
Dividends paid on preferred stock (in shares) 690,910 0 0        
Conversion of preferred stock 8 0 (24) 16 0 0 0
Conversion of preferred stock (in shares) 833,873 0 (2,416,675)        
Exercise of stock options 15 0 0 2,758 0 0 2,773
Exercise of stock options (in shares) 1,501,993 3,450 0        
Vesting of stock options 0 0 0 446 0 0 446
Compensation expense for issuance of stock options 0 0 0 5,092 0 0 5,092
Forfeiture since inception of stock options 0 0 0 (1,241) 0 0 (1,241)
Exercise of warrants 82 0 0 14,267 0 0 14,349
Exercise of warrants (in shares) 8,223,484 0 0        
Shares and warrants issued as compensation, in connection with conversion of short-term borrowings and as settlement of Consent Solicitation lawsuit 4 1 0 3,363 0 0 3,368
Shares and warrants issued as compensation, in connection with conversion of short-term borrowings and as settlement of Consent Solicitation lawsuit (in shares) 427,761 99,216 0        
Repurchases of stock 0 (51) 0 0 0 0 (51)
Repurchases of stock (in shares) 0 (28,100) 0        
Shares returned due to relevant technology milestones not being fully achieved and as settlement of a dispute with a former director 0 (4) 0 (1) 0 0 (5)
Shares returned due to relevant technology milestones not being fully achieved and as settlement of a dispute with a former director (in shares) (3,450) (414,059) 0        
Deficit accumulated from inception 0 0 0 0 (45,815) 0 (45,815)
Change in unrealized loss on investments 0 0 0 0 0 (24) (24)
Balance at Dec. 31, 2008 253 (51) 0 57,344 (47,314) (24) 10,208
Balance (in shares) at Dec. 31, 2008 25,383,354 (28,100) 0        
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Compensation expense for issuance of stock options 0 0 0 1,579 0 0 1,579
Sale of stock (including 1,043,478 warrants to purchase one share of common stock at $3.99) 9 0 0 467 0 0 476
Sale of stock (including 1,043,478 warrants to purchase one share of common stock at $3.99) (in shares) 869,565 0 0        
Exercise of warrants 1 0 0 355 0 0 356
Exercise of warrants (in shares) 103,512 0 0        
Sale of stock, net of expenses 98 0 0 32,355 0 0 32,453
Sale of stock, net of expenses (in shares) 9,775,000 0 0        
Net loss 0 0 0 0 (22,057) 0 (22,057)
Change in unrealized loss on investments 0 0 0 0 0 8 8
Total comprehensive loss: 0 0 0 0 0 0 (22,049)
Compensation expense for restricted stock 1 0 0 735 0 0 736
Compensation expense for restricted stock (in shares) 91,666 0 0        
Balance at Dec. 31, 2009 362 (51) 0 92,835 (69,371) (16) 23,759
Balance (in shares) at Dec. 31, 2009 36,223,097 (28,100) 0        
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Compensation expense for issuance of stock options 0 0 0 3,839 0 0 3,839
Exercise of warrants and options, common stock surrendered upon restricted stock vesting 12 0 0 3,830 0 0 3,842
Exercise of warrants and options, common stock surrendered upon restricted stock vesting (in shares) 1,206,007 0 0        
Fair value of warrants reclassified from liability to additional paid-in capital upon exercise 0 0 0 9,154 0 0 9,154
Sale of stock, net of expenses 52 0 0 33,454 0 0 33,506
Sale of stock, net of expenses (in shares) 5,185,000 0 0        
Net loss 0 0 0 0 (46,684) 0 (46,684)
Change in unrealized loss on investments 0 0 0 0 0 (10) (10)
Total comprehensive loss: 0 0 0 0 0 0 (46,694)
Compensation expense for restricted stock 4 0 0 1,671 0 0 1,675
Compensation expense for restricted stock (in shares) 414,042 0 0        
Balance at Dec. 31, 2010 430 (51) 0 144,783 (116,055) (26) 29,081
Balance (in shares) at Dec. 31, 2010 43,028,146 (28,100) 0        
Increase (Decrease) in Stockholders' Equity [Roll Forward]              
Compensation expense for issuance of stock options 0 0 0 3,605 0 0 3,605
Exercise of options, common stock surrendered upon restricted stock vesting 0 0 0 82 0 0 82
Exercise of options, common stock surrendered upon restricted stock vesting (in shares) 36,272 0 0        
Sale of stock, net of expenses 50 0 0 23,491 0 0 23,541
Sale of stock, net of expenses (in shares) 5,000,000 0 0        
Net loss 0 0 0 0 (30,885) 0 (30,885)
Change in unrealized loss on investments 0 0 0 0 0 26 26
Total comprehensive loss: 0 0 0 0 0 0 (30,859)
Compensation expense for restricted stock 2 0 0 652 0 0 654
Compensation expense for restricted stock (in shares) 173,212 0 0        
Balance at Dec. 31, 2011 $ 482 $ (51) $ 0 $ 172,613 $ (146,940) $ 0 $ 26,104
Balance (in shares) at Dec. 31, 2011 48,237,630 (28,100) 0