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Income Taxes (Details) (USD $) | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010 | Dec. 31, 2009 | Dec. 31, 2008
Provision for income taxes [Abstract] |  |  |  |  |
Income taxes using U.S. federal statutory rate | $ (17,621,000) | $ (10,501,000) | $ (15,872,000) |  |
Amortization of Gain on IP Migration | 754,000 | 0 | 0 |  |
State income taxes, net of federal benefit | (4,299,000) | (3,418,000) | (4,276,000) |  |
Foreign rate differential | 3,716,000 | 52,000 | 0 |  |
Valuation allowance | 17,561,000 | 20,563,000 | 15,041,000 | 5,900,000 | 3,200,000
Derivative charge | (734,000) | (5,292,000) | 5,423,000 |  |
Stock option exercises and cancellations | 310,000 | 102,000 | 0 |  |
Research and development credits | 326,000 | (1,633,000) | (519,000) |  |
Other | (13,000) | 127,000 | 203,000 |  |
Total | 0 | 0 | 0 |  |
Deferred tax assets [Abstract] |  |  |  |  |
Employee compensation accruals | 6,176,000 | 4,973,000 |  |  |
Accrued liabilities | 299,000 | 283,000 |  |  |
Research tax credits | 2,382,000 | 2,708,000 |  |  |
Other | 31,000 | 3,000 |  |  |
Net operating losses | 63,765,000 | 47,118,000 |  |  |
Total deferred tax assets | 72,653,000 | 55,085,000 |  |  |
Deferred tax liability [Abstract] |  |  |  |  |
Total deferred tax liabilities | 0 | 0 |  |  |
Valuation allowance | 72,653,000 | 55,085,000 |  |  |
Net deferred tax assets | 0 | 0 |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |
Percentage of valuation allowance (in hundredths) | 100.00% |  |  |  |
Valuation allowance increased | 17,561,000 | 20,563,000 | 15,041,000 | 5,900,000 | 3,200,000
Tax benefit related to the exercise of non qualified stock options | 1,000,000 |  |  |  |
Federal [Member] |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |
Operating loss carryforwards | 138,100,000 | 122,100,000 |  |  |
Operating loss carryforwards, expiration dates | 2032 |  |  |  |
Operating loss carryforwards, amount subject to limitations | 8,600,000 |  |  |  |
Operating loss carryforwards, annual limitation | 123,000 |  |  |  |
Operating loss carryforwards, net of limitations | 131,900,000 |  |  |  |
State and city [Member] |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |
Operating loss carryforwards | 231,000,000 | 180,200,000 |  |  |
Operating loss carryforwards, expiration dates | 2032 |  |  |  |
Foreign [Member] |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |
Operating loss carryforwards | $ 6,700,000 | $ 200,000 | $ 0 |  |

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from accrued liabilities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 109 -Paragraph 11 -Subparagraph b -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 25 -Paragraph 20 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6969291&loc=d3e28680-109314 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 6 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32621-109319 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 109 -Paragraph 43 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32632-109319 + Details
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- Definition Tax benefits realized from the exercise of stock options resulting in reductions in the entity's income taxes, which increases net cash provided by operating activities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 20 -Section 55 -Paragraph 20 -URI http://asc.fasb.org/extlink&oid=6576910&loc=d3e11283-113907 + Details
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