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Consolidated Statements of Cash Flows (USD $) In Thousands, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2012 | Dec. 31, 2011 | Dec. 31, 2010
Cash flows from operating activities: |  |  |
Net loss | $ (51,868) | $ (30,885) | $ (46,684)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock option compensation expense | 2,807 | 3,605 | 3,839
Restricted stock and warrant compensation expense | 1,018 | 654 | 1,675
Depreciation expense | 1,331 | 1,035 | 472
Loss on disposal of equipment | 0 | 0 | 7
Warrant liability fair value adjustment | (2,159) | (15,566) | 15,951
Non-cash interest income | 2 | 0 | (3)
Changes in assets and liabilities: |  |  |
Decrease (increase) in prepaid expenses and other current assets | (228) | 553 | (1,001)
Decrease in investment in common stock | 0 | 26 | 10
Decrease (increase) in accounts receivable | (144) |  |
Decrease (increase) in inventories | (1,105) | 0 | 0
Increase (decrease) in accounts payable and accrued expenses | 331 | 3,206 | 1,351
Deferred revenue | 9 | 0 | 300
Net cash used in operating activities | (50,006) | (37,372) | (24,083)
Cash flows from investing activities: |  |  |
Purchase of property, plant, and equipment | (2,120) | (2,607) | (1,638)
Purchase of short-term investments and marketable equity securities | 0 | (4,980) | (3,235)
Proceeds from maturities of short-term investments | 4,980 | 1,492 | 1,743
Net cash (used in) provided by investing activities | 2,860 | (6,095) | (3,130)
Cash flows from financing activities: |  |  |
Net proceeds from sale of stock and exercise of stock options and warrants | 45,058 | 23,623 | 37,348
Net cash provided by financing activities | 45,058 | 23,623 | 37,348
Foreign currency effects on cash | 37 | 0 | 0
(Decrease) increase in cash and cash equivalents | (2,051) | (19,844) | 10,135
Cash and cash equivalents at beginning of period | 25,777 | 45,621 | 35,486
Cash and cash equivalents at end of period | 23,726 | 25,777 | 45,621
Supplemental non-cash activities: |  |  |
Cashless exercise of stock options and shares surrendered upon restricted stock vesting |  | (61) | 700
Fair value of warrants issued | 4,055 | 0 | 0
Fair value of warrants reclassified from liability to additional paid-in capital upon exercise | $ 908 | $ 0 | $ 9,154

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- Definition The value of the noncash (or part noncash) consideration given (for example, liability, equity) in a transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of a transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4313-108586 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 32 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 15 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3213-108585 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 17 -Subparagraph c -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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- Definition The cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 19 -Subparagraph a -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 18 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3255-108585 + Details
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- Definition The noncash expense that represents the cost of restricted stock or unit distributed to employees as compensation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 28 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6943989&loc=d3e3602-108585 + Details
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