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Stockholders' Equity (Details) (USD $)	3 Months Ended								12 Months Ended																								1 Months Ended			12 Months Ended																	12 Months Ended
	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Dec. 31, 2011	Sep. 30, 2011	Jun. 30, 2011	Mar. 31, 2011	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009	Dec. 31, 2007	Dec. 31, 2012 Stock Options [Member]	Dec. 31, 2011 Stock Options [Member]	Dec. 31, 2010 Stock Options [Member]	Dec. 31, 2012 Stock Options [Member] Selling, General and Administrative [Member]	Dec. 31, 2011 Stock Options [Member] Selling, General and Administrative [Member]	Dec. 31, 2010 Stock Options [Member] Selling, General and Administrative [Member]	Dec. 31, 2012 Stock Options [Member] Research and Development [Member]	Dec. 31, 2011 Stock Options [Member] Research and Development [Member]	Dec. 31, 2010 Stock Options [Member] Research and Development [Member]	Dec. 31, 2012 Restricted Stock [Member]	Dec. 31, 2011 Restricted Stock [Member]	Dec. 31, 2010 Restricted Stock [Member]	Dec. 31, 2012 Restricted Stock [Member] Selling, General and Administrative [Member]	Dec. 31, 2011 Restricted Stock [Member] Selling, General and Administrative [Member]	Dec. 31, 2010 Restricted Stock [Member] Selling, General and Administrative [Member]	Dec. 31, 2012 Restricted Stock [Member] Research and Development [Member]	Dec. 31, 2011 Restricted Stock [Member] Research and Development [Member]	Dec. 31, 2010 Restricted Stock [Member] Research and Development [Member]	Dec. 31, 2012 2004 Stock Incentive Plan [Member]	May 31, 2012 2009 Stock Incentive Plan [Member]	Dec. 31, 2012 2009 Stock Incentive Plan [Member]	Dec. 31, 2011 2009 Stock Incentive Plan [Member]	Dec. 31, 2012 Cowen and Company, LLC [Member]	Dec. 31, 2011 Cowen and Company, LLC [Member]	Dec. 31, 2012 Terrapin Opportunity, L.P. [Member]	Dec. 31, 2012 Minimum [Member]	Dec. 31, 2011 Minimum [Member]	Dec. 31, 2010 Minimum [Member]	Dec. 31, 2012 Minimum [Member] Stock Options [Member]	Dec. 31, 2011 Minimum [Member] Stock Options [Member]	Dec. 31, 2010 Minimum [Member] Stock Options [Member]	Dec. 31, 2012 Maximum [Member]	Dec. 31, 2011 Maximum [Member]	Dec. 31, 2010 Maximum [Member]	Dec. 31, 2012 Maximum [Member] Stock Options [Member]	Dec. 31, 2011 Maximum [Member] Stock Options [Member]	Dec. 31, 2010 Maximum [Member] Stock Options [Member]	Dec. 31, 2007 2007 Warrants [Member]	Dec. 31, 2012 2007 Warrants [Member]	Dec. 31, 2012 2012 Warrants [Member]	Dec. 31, 2012 2009 Warrants [Member]	Dec. 31, 2009 2009 Warrants [Member]	Dec. 31, 2012 Warrants [Member]	Dec. 31, 2011 Warrants [Member]	Dec. 31, 2010 Warrants [Member]	Dec. 31, 2009 Warrants [Member]	Dec. 31, 2012 Warrants [Member] Minimum [Member]	Dec. 31, 2010 Warrants [Member] Minimum [Member]	Dec. 31, 2012 Warrants [Member] Maximum [Member]	Dec. 31, 2010 Warrants [Member] Maximum [Member]
Stock Issuances [Abstract]
Sale of stock, net of expenses (in shares)									15,333,340	5,000,000	5,185,000	869,565	3,833,108																							8,100,000		1,700,000
Warrants issued (in shares)																																																			1,916,554		4,600,002		1,043,478
Proceeds from issuance of private placement												$ 3,000,000	$ 13,300,000																							$ 21,500,000		$ 1,900,000
Estimated fair value allocated to warrants issued																																																			4,300,000		3,400,000		2,200,000
Warrants exercisable per share price (in dollars per share)																																																				$ 1.49	$ 1.20	$ 1.20		$ 1.20					$ 3.44		$ 3.60
Number of warrants outstanding (in shares)																																																				3,392,592	4,599,102	1,043,478		5,642,580	2,512,934	2,512,934	3,746,184
Net proceeds from issuance of private placement									21,100,000			2,700,000
Term period for warrants																																																					3 years	5 years
Net proceeds from issuance of common stock										23,500,000	33,500,000																									17,600,000	39,800,000
Shares available under program (in shares)																																				21,500,000		32,900,000
Common stock, par value under sales agreement (in dollars per share)																																					$ 0.01
Amount to be purchased by party under agreement																																						35,000,000
Term of purchase agreement																																						24 months
Derivative instrument income	1,134,000	446,000	917,000	(338,000)	702,000	3,872,000	5,027,000	5,966,000	2,200,000
Derivative instrument liabilities	3,400,000								3,400,000
Fair value assumptions used to determine the value of warrants [Abstract]
Expected volatility (in hundredths)																																																					86.08%	87.14%
Risk free interest rate (in hundredths)																																																					0.30%	0.20%
Expected life (in years)																																																					2 years 4 months 24 days	1 year 4 months 24 days
Warrants outstanding [Roll Forward]
Outstanding, beginning of period (in shares)																																																				3,392,592				2,512,934	2,512,934	3,746,184
Issued (in shares)																																																								6,523,120	0	0
Exercised (in shares)																																																								(2,975,457)	0	(1,159,000)
Expired (in shares)																																																								(418,017)	0	(74,250)
Outstanding, end of period (in shares)																																																				3,392,592	4,599,102	1,043,478		5,642,580	2,512,934	2,512,934	3,746,184
Warrants, Exercise Price per Share [Roll Forward]
Outstanding, beginning of period (in dollars per share)																																																				$ 1.49								$ 3.44	$ 3.44	$ 3.60	$ 3.91
Issued (in dollars per share)																																																												$ 1.49		$ 3.03
Exercised (in dollars per share)																																																												$ 1.49	$ 3.44	$ 1.65	$ 3.91
Expired (in dollars per share)																																																								$ 1.49		$ 3.91
Outstanding, end of period (in dollars per share)																																																				$ 1.49	$ 1.20	$ 1.20		$ 1.20					$ 3.44		$ 3.60
Warrants, Weighted Average Exercise Price [Roll Forward]
Outstanding, beginning of period (in dollars per share)																																																								$ 3.51	$ 3.51	$ 3.52
Issued (in dollars per share)																																																								$ 1.65
Exercised (in dollars per share)																																																								$ 1.49		$ 3.52
Expired (in dollars per share)																																																								$ 1.49		$ 3.91
Outstanding, end of period (in dollars per share)																																																								$ 1.20	$ 3.51	$ 3.51	$ 3.52
Weighted average remaining life																																																								2 years 2 months 27 days	1 year 5 months 12 days	2 years 5 months 12 days	3 years 29 days
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares reserved for the issuance (in shares)																																3,000,000		6,500,000	4,200,000
Increased number of shares (in shares)																																	2,300,000
Term of options														10 years
Stock Options, Number of Options [Roll Forward]
Outstanding, beginning of period (in shares)				4,129,749				3,760,650	4,129,749	3,760,650	3,345,000
Granted (in shares)									1,207,452	671,326	700,650
Expired (in shares)									(420,000)	(120,000)	(120,000)
Forfeited (in shares)									(128,314)	(136,900)	(25,000)
Exercised (in shares)									0	(45,327)	(140,000)
Outstanding, end of period (in shares)	4,788,887				4,129,749				4,788,887	4,129,749	3,760,650	3,345,000
Exercisable (in shares)	3,105,535								3,105,535
Stock Options, Exercise Price per Share [Roll Forward]
Outstanding, beginning of period (in dollars per share)																																							$ 1.23	$ 1.23	$ 1.23				$ 15.54	$ 15.54	$ 6.18
Granted (in dollars per share)																																							$ 1.43	$ 2.00	$ 5.28				$ 4.60	$ 9.18	$ 15.54
Expired (in dollars per share)										$ 3.28																													$ 1.88		$ 2.78				$ 5.85		$ 3.59
Forfeited (in dollars per share)																																							$ 2.26	$ 1.40	$ 4.12				$ 9.18	$ 9.93	$ 6.18
Exercised (in dollars per share)																																								$ 2.44	$ 1.43					$ 3.28	$ 6.18
Outstanding, end of period (in dollars per share)																																							$ 1.23	$ 1.23	$ 1.23				$ 15.54	$ 15.54	$ 15.54
Exercisable (in dollars per share)																																							$ 1.23						$ 15.54
Stock Options, Weighted Average Exercise Price [Roll Forward]
Outstanding, beginning of period (in dollars per share)				$ 5.09				$ 4.88	$ 5.09	$ 4.88	$ 3.72
Granted (in dollars per share)									$ 3.80	$ 5.72	$ 9.81
Expired (in dollars per share)									$ 4.81	$ 3.28	$ 3.25
Forfeited (in dollars per share)									$ 5.05	$ 4.65	$ 4.81
Exercised (in dollars per share)										$ 3.18	$ 3.52
Outstanding, end of period (in dollars per share)	$ 4.79				$ 5.09				$ 4.79	$ 5.09	$ 4.88	$ 3.72
Exercisable (in dollars per share)	$ 4.85								$ 4.85
Stock Options, Weighted Average Remaining Life Years [Abstract]
Outstanding									6 years 10 months 17 days	6 years 4 months 17 days	6 years 7 months 24 days	6 years 6 months 29 days
Exercisable									5 years 9 months 18 days
Assumptions used to determine the fair value of stock options [Abstract]
Weighted average risk-free interest rate (in hundredths)														1.11%	2.07%	2.54%
Weighted average expected volatility (in hundredths)														79.89%	74.64%	73.80%
Expected volatility (in hundredths)																																										77.37%	7388.00%	7216.00%				84.81%	7911.00%	7540.00%
Dividend yield (in hundredths)														0.00%	0.00%	0.00%
Weighted average expected option term														6 years 2 months 1 day	6 years	5 years 10 months 13 days
Weighted average grant date fair value (in dollars per share)														$ 2.59	$ 3.79	$ 6.30
Non-vested Options, Number of Options [Roll Forward]
Non-vested, beginning of period (in shares)														1,158,368	1,362,316
Granted (in shares)														1,207,452	670,826
Vested (in shares)														(570,518)	(812,874)
Forfeited (in shares)														(111,950)	(61,900)
Non-vested, end of period (in shares)														1,683,352	1,158,368	1,362,316
Non-vested Options, Weighted Average Fair Value [Roll Forward]
Non-vested, beginning of period (in dollars per share)														$ 6.44	$ 6.39
Granted (in dollars per share)														$ 3.80	$ 5.72
Vested (in dollars per share)														$ 6.38	$ 5.60
Forfeited (in dollars per share)														$ 4.79	$ 8.58
Non-vested, end of period (in dollars per share)														$ 4.68	$ 6.44	$ 6.39
Additional compensation expense relating to stock options														2,000,000
Additional compensation expense relating to restricted stock																							700,000
Remaining average recognition period for unrecognized compensation expense														1 year 4 months 24 days									1 year 2 months 12 days
Aggregate intrinsic value of options outstanding and exercisable														0
Closing stock price (in dollars per share)														$ 1.23
Restricted Stock, Number of Shares [Roll Forward]
Outstanding, beginning of period (in shares)																							193,532	67,590
Granted (in shares)																							429,720	188,277
Vested (in shares)																							(100,751)	(47,270)
Forfeited (in shares)																							(21,033)	(15,065)
Outstanding, end of period (in shares)																							501,468	193,532	67,590
Restricted Stock, Weighted Average Grant Date Fair Value [Roll Forward]
Non-vested, beginning of period (in dollars per share)																							$ 5.84	$ 6.71
Granted (in dollars per share)																							$ 2.83	$ 5.67
Vested (in dollars per share)																							$ 6.18	$ 5.62
Forfeited (in dollars per share)																							$ 4.39	$ 8.35
Non-vested, end of period (in dollars per share)																							$ 3.26	$ 5.84	$ 6.71
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Compensation expense recognized granted to employees														$ 2,800,000	$ 3,600,000	$ 3,600,000	$ 1,700,000	$ 2,200,000	$ 2,500,000	$ 1,100,000	$ 1,400,000	$ 1,100,000	$ 1,000,000	$ 600,000	$ 1,600,000	$ 700,000	$ 500,000	$ 800,000	$ 300,000	$ 100,000	$ 800,000

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Weighted average fair value as of the grant date of stock options that were not exercised or put into effect as a result of the occurrence of a terminating event.

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Exercise price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Number of warrants issued during the period to purchase common shares.

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