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Income Taxes (Details) (USD $)
 12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Dec. 31, 2008
Provision for income taxes [Abstract]          
Income taxes using U.S. federal statutory rate $ (17,621,000) $ (10,501,000) $ (15,872,000)    
Amortization of Gain on IP Migration 754,000 0 0    
State income taxes, net of federal benefit (4,299,000) (3,418,000) (4,276,000)    
Foreign rate differential 3,716,000 52,000 0    
Valuation allowance 17,561,000 20,563,000 15,041,000 5,900,000 3,200,000
Derivative charge (734,000) (5,292,000) 5,423,000    
Stock option exercises and cancellations 310,000 102,000 0    
Research and development credits 326,000 (1,633,000) (519,000)    
Other (13,000) 127,000 203,000    
Total 0 0 0    
Deferred tax assets [Abstract]          
Employee compensation accruals 6,176,000 4,973,000      
Accrued liabilities 299,000 283,000      
Research tax credits 2,382,000 2,708,000      
Other 31,000 3,000      
Net operating losses 63,765,000 47,118,000      
Total deferred tax assets 72,653,000 55,085,000      
Deferred tax liability [Abstract]          
Total deferred tax liabilities 0 0      
Valuation allowance 72,653,000 55,085,000      
Net deferred tax assets 0 0      
Operating Loss Carryforwards [Line Items]          
Percentage of valuation allowance (in hundredths) 100.00%        
Valuation allowance increased 17,561,000 20,563,000 15,041,000 5,900,000 3,200,000
Tax benefit related to the exercise of non qualified stock options 1,000,000        
Federal [Member]
          
Operating Loss Carryforwards [Line Items]          
Operating loss carryforwards 138,100,000 122,100,000      
Operating loss carryforwards, expiration dates 2032        
Operating loss carryforwards, amount subject to limitations 8,600,000        
Operating loss carryforwards, annual limitation 123,000        
Operating loss carryforwards, net of limitations 131,900,000        
State and city [Member]
          
Operating Loss Carryforwards [Line Items]          
Operating loss carryforwards 231,000,000 180,200,000      
Operating loss carryforwards, expiration dates 2032        
Foreign [Member]
          
Operating Loss Carryforwards [Line Items]          
Operating loss carryforwards $ 6,700,000 $ 200,000 $ 0