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Summary of Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2013
Summary of Significant Accounting Policies [Abstract]  
Calculation of net loss and number of shares used to compute basic and diluted earnings per share
The calculation of net loss and the number of shares used to compute basic and diluted earnings per share for the years ended December 31, 2013, 2012 and 2011 are as follows:

(in thousands, except share data)
 
2013
  
2012
  
2011
 
Net loss – basic
 
$
(30,324
)
 
$
(51,868
)
 
$
(30,885
)
Adjust for gain on warrant derivative liability
  
(1,835
)
  
—
   
—
 
Net loss - diluted
  
(32,159
)
  
(51,868
)
  
(30,885
)
Net loss per share – basic
  
(0.30
)
  
(0.85
)
  
(0.68
)
Weighted average shares outstanding – basic
  
100,809,824
   
61,275,527
   
45,236,921
 
Warrant exercises
  
4,294,353
   
—
   
—
 
Weighted average shares outstanding – diluted
  
105,104,177
   
61,275,527
   
45,236,921
 
Net loss per share – diluted
  
(0.31
)
  
(0.85
)
  
(0.68
)
Shares excluded from the computation of diluted EPS
Shares excluded from the computation of diluted EPS:
 
 
 
2013
  
2012
  
2011
 
Stock options
  
4,035,143
   
4,788,887
   
4,129,749
 
Unvested restricted shares
  
325,722
   
501,468
   
193,532
 
Warrants
  
9,432,000
   
5,642,580
   
2,512,934
 
Total
  
13,792,865
   
10,932,935
   
6,836,215