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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2013
Income Taxes [Abstract]  
Income tax reconciliation
The provision for income taxes differs from the amount computed by applying the statutory rate as follows: 
 
 
 
Year Ended December 31,
 
(in thousands)
 
2013
  
2012
  
2011
 
Income taxes using U.S. federal statutory rate
 
$
(10,309
)
 
$
(17,621
)
 
$
(10,501
)
Amortization of gain on IP migration
  
781
   
754
   
 
State income taxes, net of federal benefit
  
(1,390
)
  
(4,299
)
  
(3,418
)
Foreign rate differential
  
2,761
   
3,716
   
52
 
Valuation allowance
  
7,683
   
17,561
   
20,563
 
Derivative charge
  
(937
)
  
(734
)
  
(5,292
)
Stock option exercises and cancellations
  
1,589
   
310
   
102
 
Research and development credits
  
(1,090
)
  
326
 
  
(1,633
)
Other
  
912
   
(13
)
  
127
 
Total
 
$
  
$
  
$
 
Significant components of deferred tax assets
Significant components of the Company’s deferred tax assets are as follows: 
 
(in thousands)
 
2013
  
2012
 
Deferred tax assets:
 
  
 
Employee compensation accruals
 
$
4,077
  
$
6,176
 
Accrued liabilities
  
870
   
299
 
Research tax credits
  
3,472
   
2,382
 
Other
  
79
   
31
 
Net operating losses
  
71,874
   
63,765
 
Total deferred tax assets
  
80,372
   
72,653
 
 
        
Deferred tax liability:
        
Total deferred tax liabilities
  
   
 
 
        
Valuation allowance
  
80,372
   
72,653
 
Net deferred tax assets
 
$
  
$