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Stockholders' Equity (Details) (USD $)	1 Months Ended			3 Months Ended								12 Months Ended																						1 Months Ended		3 Months Ended	12 Months Ended									1 Months Ended	12 Months Ended	1 Months Ended	12 Months Ended	0 Months Ended	12 Months Ended							12 Months Ended			0 Months Ended	12 Months Ended	0 Months Ended	12 Months Ended		12 Months Ended		3 Months Ended
	May 31, 2012	Jul. 31, 2011	Jun. 30, 2009	Dec. 31, 2013	Sep. 30, 2013	Jun. 30, 2013	Mar. 31, 2013	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Dec. 31, 2013	Dec. 31, 2008	Dec. 31, 2013 Stock Options [Member]	Dec. 31, 2012 Stock Options [Member]	Dec. 31, 2011 Stock Options [Member]	Dec. 31, 2010 Stock Options [Member]	Dec. 31, 2013 Stock Options [Member] Selling, General and Administrative [Member]	Dec. 31, 2012 Stock Options [Member] Selling, General and Administrative [Member]	Dec. 31, 2011 Stock Options [Member] Selling, General and Administrative [Member]	Dec. 31, 2013 Stock Options [Member] Research and Development [Member]	Dec. 31, 2012 Stock Options [Member] Research and Development [Member]	Dec. 31, 2011 Stock Options [Member] Research and Development [Member]	Dec. 31, 2013 Restricted Stock [Member]	Dec. 31, 2012 Restricted Stock [Member]	Dec. 31, 2011 Restricted Stock [Member]	Dec. 31, 2013 Restricted Stock [Member] Selling, General and Administrative [Member]	Dec. 31, 2012 Restricted Stock [Member] Selling, General and Administrative [Member]	Dec. 31, 2011 Restricted Stock [Member] Selling, General and Administrative [Member]	Dec. 31, 2013 Restricted Stock [Member] Research and Development [Member]	Dec. 31, 2012 Restricted Stock [Member] Research and Development [Member]	Dec. 31, 2011 Restricted Stock [Member] Research and Development [Member]	Dec. 31, 2013 2004 Stock Incentive Plan [Member]	May 31, 2012 2009 Stock Incentive Plan [Member]	Dec. 31, 2013 2009 Stock Incentive Plan [Member]	Mar. 31, 2013 Cowen and Company, LLC [Member]	Dec. 31, 2013 Cowen and Company, LLC [Member]	Dec. 31, 2013 Terrapin Opportunity, L.P. [Member]	Dec. 31, 2012 Terrapin Opportunity, L.P. [Member]	Dec. 31, 2013 Minimum [Member] Stock Options [Member]	Dec. 31, 2012 Minimum [Member] Stock Options [Member]	Dec. 31, 2011 Minimum [Member] Stock Options [Member]	Dec. 31, 2013 Maximum [Member] Stock Options [Member]	Dec. 31, 2012 Maximum [Member] Stock Options [Member]	Dec. 31, 2011 Maximum [Member] Stock Options [Member]	May 31, 2012 2012 Warrants [Member]	Dec. 31, 2013 2012 Warrants [Member]	Jun. 30, 2009 2009 Warrants [Member]	Dec. 31, 2013 2009 Warrants [Member]	Oct. 28, 2013 Warrants [Member]	Dec. 31, 2013 Warrants [Member]	Dec. 31, 2012 Warrants [Member]	Dec. 31, 2011 Warrants [Member]	Dec. 31, 2010 Warrants [Member]	Dec. 31, 2012 Warrants [Member] Minimum [Member]	Dec. 31, 2013 Warrants [Member] Minimum [Member]	Dec. 31, 2010 Warrants [Member] Minimum [Member]	Dec. 31, 2012 Warrants [Member] Maximum [Member]	Dec. 31, 2013 Warrants [Member] Maximum [Member]	Dec. 31, 2010 Warrants [Member] Maximum [Member]	Oct. 28, 2013 2013 Warrants [Member]	Dec. 31, 2013 2013 Warrants [Member]	Oct. 28, 2013 2013 Warrants [Member] Terrapin Opportunity, L.P. [Member]	Dec. 31, 2013 Sales Agreement March 2013 [Member] Cowen and Company, LLC [Member]	Mar. 13, 2013 Sales Agreement March 2013 [Member] Cowen and Company, LLC [Member]	Dec. 31, 2012 CEFF [Member] Terrapin Opportunity, L.P. [Member]	Dec. 31, 2013 CEFF [Member] Terrapin Opportunity, L.P. [Member]	Mar. 31, 2013 Sales Agreement December 2011 [Member] Cowen and Company, LLC [Member]
Stock Issuances [Abstract]
Sale of stock, net of expenses (in shares)	15,300,000	5,000,000	900,000										3,900,000																									5,600,000																							21,000,000			16,400,000				14,200,000
Warrants issued (in shares)																																														4,600,000		1,000,000													9,400,000
Proceeds from issuance of private placement	$ 21,500,000		$ 3,000,000																																	$ 20,900,000		$ 9,000,000																							$ 7,500,000			$ 5,000,000		$ 2,100,000
Amount available under committed equity financing facility																																																																	50,000,000		23,900,000
Estimated fair value allocated to warrants issued																																														3,400,000		2,200,000															1,900,000
Warrants exercisable per share price (in dollars per share)																																															$ 0.16		$ 0.16							$ 0.16	$ 3.44		$ 0.44	$ 3.60	$ 0.44
Number of warrants outstanding (in shares)																																															4,400,000		1,000,000		14,871,891	5,642,580	2,512,934	2,512,934							9,400,000
Net proceeds from issuance of private placement	21,100,000		2,700,000
Term period for warrants																																															3 years		5 years	5 years
Net proceeds from issuance of common stock		23,500,000																																		20,800,000	39,800,000	8,900,000																									6,900,000	4,800,000
Shares available under program (in shares)																																				0
Common stock, par value under sales agreement (in dollars per share)																																					$ 0.01																												$ 0.01
Amount to be purchased by party under agreement																																							35,000,000
Term of purchase agreement																																							24 months
Derivative instrument income				410,000	(497,000)	5,115,000	(2,272,000)	1,134,000	446,000	917,000	(338,000)	2,800,000
Derivative instrument liabilities				2,300,000								2,300,000
Fair value assumptions used to determine the value of warrants [Abstract]
Expected volatility (in hundredths)																																															106.77%		128.50%													91.00%
Risk free interest rate (in hundredths)																																															0.26%		0.10%													2.00%
Expected life (in years)																																															1 year 4 months 28 days		0 years 5 months 12 days													5 years
Warrants outstanding [Roll Forward]
Outstanding, beginning of period (in shares)																																																			5,642,580	2,512,934	2,512,934
Issued (in shares)																																																			9,432,000	6,523,120	0
Exercised (in shares)																																																			(202,689)	(2,975,457)	0
Expired (in shares)																																																			0	(418,017)	0
Outstanding, end of period (in shares)																																															4,400,000		1,000,000		14,871,891	5,642,580	2,512,934	2,512,934							9,400,000
Warrants, Exercise Price per Share [Roll Forward]
Outstanding, beginning of period (in dollars per share)																																																							$ 3.44	$ 0.16	$ 3.44	$ 3.60	$ 0.44	$ 3.60
Issued (in dollars per share)																																																							$ 1.49			$ 3.03
Exercised (in dollars per share)																																																							$ 1.49			$ 1.65
Outstanding, end of period (in dollars per share)																																															$ 0.16		$ 0.16							$ 0.16	$ 3.44		$ 0.44	$ 3.60	$ 0.44
Warrants, Weighted Average Exercise Price [Roll Forward]
Outstanding, beginning of period (in dollars per share)																																																			$ 1.20	$ 3.51	$ 3.51
Issued (in dollars per share)																																																			$ 0.44	$ 1.65
Exercised (in dollars per share)																																																			$ 1.20	$ 1.49
Expired (in dollars per share)																																																				$ 1.49
Outstanding, end of period (in dollars per share)																																																			$ 0.34	$ 1.20	$ 3.51	$ 3.51
Weighted average remaining life																																																			3 years 6 months 4 days	2 years 2 months 26 days	1 year 5 months 12 days	2 years 5 months 12 days
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares reserved for the issuance (in shares)																																	3,000,000	4,200,000	6,500,000
Increased number of shares (in shares)																																		2,300,000
Term of options														10 years
Stock Options, Number of Options [Roll Forward]
Outstanding, beginning of period (in shares)														4,788,887	4,129,749	3,760,650
Granted (in shares)														2,085,717	1,207,452	671,326
Expired (in shares)														(270,000)	(420,000)	(120,000)
Forfeited (in shares)														(2,569,461)	(128,314)	(136,900)
Exercised (in shares)																(45,327)
Outstanding, end of period (in shares)														4,035,143	4,788,887	4,129,749	3,760,650
Exercisable (in shares)														2,136,785
Stock Options, Exercise Price per Share [Roll Forward]
Outstanding, beginning of period (in dollars per share)																																								$ 1.23	$ 1.23	$ 1.23	$ 15.54	$ 15.54	$ 15.54
Granted (in dollars per share)																																								$ 0.30	$ 1.43	$ 2.00	$ 2.13	$ 4.60	$ 9.18
Expired (in dollars per share)																																								$ 1.23	$ 1.88	$ 3.28	$ 1.87	$ 5.85	$ 3.28
Forfeited (in dollars per share)																																								$ 0.38	$ 2.26	$ 1.40	$ 12.34	$ 9.18	$ 9.93
Exercised (in dollars per share)																																										$ 2.44			$ 3.28
Outstanding, end of period (in dollars per share)																																								$ 0.30	$ 1.23	$ 1.23	$ 15.54	$ 15.54	$ 15.54
Exercisable (in dollars per share)																																								$ 1.24			$ 15.54
Stock Options, Weighted Average Exercise Price [Roll Forward]
Outstanding, beginning of period (in dollars per share)														$ 4.79	$ 5.09	$ 4.88
Granted (in dollars per share)														$ 1.09	$ 3.80	$ 5.72
Expired (in dollars per share)														$ 1.53	$ 4.81	$ 3.28
Forfeited (in dollars per share)														$ 3.97	$ 5.05	$ 4.65
Exercised (in dollars per share)																$ 3.18
Outstanding, end of period (in dollars per share)														$ 3.62	$ 4.79	$ 5.09	$ 4.88
Exercisable (in dollars per share)														$ 5.68
Stock Options, Weighted Average Remaining Life Years [Abstract]
Outstanding														2 years 1 month 17 days	6 years 10 months 17 days	6 years 4 months 17 days	6 years 7 months 24 days
Exercisable														5 years 6 months 22 days
Assumptions used to determine the fair value of stock options [Abstract]
Weighted average risk-free interest rate (in hundredths)														1.30%	1.11%	2.07%
Weighted average expected volatility (in hundredths)														92.31%	79.89%	74.64%
Expected volatility (in hundredths)																																								86.16%	77.37%	73.88%	97.21%	84.81%	79.11%
Dividend yield (in hundredths)														0.00%	0.00%	0.00%
Weighted average expected option term														5 years 7 months 28 days	6 years 2 months 1 day	6 years
Weighted average grant date fair value (in dollars per share)														$ 0.81	$ 2.59	$ 3.79
Non-vested Options, Number of Options [Roll Forward]
Non-vested, beginning of period (in shares)														1,683,352	1,158,368
Granted (in shares)														2,085,717	1,207,452
Vested (in shares)														(686,232)	(570,518)
Forfeited (in shares)														(1,184,479)	(111,950)
Non-vested, end of period (in shares)														1,898,358	1,683,352	1,158,368
Non-vested Options, Weighted Average Fair Value [Roll Forward]
Non-vested, beginning of period (in dollars per share)														$ 4.68	$ 6.44
Granted (in dollars per share)														$ 1.09	$ 3.80
Vested (in dollars per share)														$ 5.38	$ 6.38
Forfeited (in dollars per share)														$ 3.37	$ 4.79
Non-vested, end of period (in dollars per share)														$ 1.30	$ 4.68	$ 6.44
Additional compensation expense relating to stock options														600,000
Additional compensation expense relating to restricted stock																								100,000
Remaining average recognition period for unrecognized compensation expense														1 year 3 months										0 years 8 months 12 days
Aggregate intrinsic value of options outstanding and exercisable														0
Closing stock price (in dollars per share)														$ 0.26
Restricted Stock, Number of Shares [Roll Forward]
Outstanding, beginning of period (in shares)																								501,468	193,532
Granted (in shares)																								276,250	429,720
Vested (in shares)																								(313,395)	(100,751)
Forfeited (in shares)																								(138,601)	(21,033)
Outstanding, end of period (in shares)																								325,722	501,468	193,532
Restricted Stock, Weighted Average Grant Date Fair Value [Roll Forward]
Non-vested, beginning of period (in dollars per share)																								$ 3.26	$ 5.84
Granted (in dollars per share)																								$ 0.42	$ 2.83
Vested (in dollars per share)																								$ 2.57	$ 6.18
Forfeited (in dollars per share)																								$ 4.32	$ 4.39
Non-vested, end of period (in dollars per share)																								$ 1.05	$ 3.26	$ 5.84
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Compensation expense recognized granted to employees														$ 200,000	$ 2,800,000	$ 3,600,000		$ 200,000	$ 1,700,000	$ 2,200,000	$ 0	$ 1,100,000	$ 1,400,000	$ 200,000	$ 1,000,000	$ 600,000	$ 200,000	$ 700,000	$ 500,000	$ 0	$ 300,000	$ 100,000

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Number of share options (or share units) exercised during the current period.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 04

-Article 3



Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 505

-SubTopic 10

-Section 50

-Paragraph 2

-URI http://asc.fasb.org/extlink&oid=6928386&loc=d3e21463-112644



Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 505

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.3-04)

-URI http://asc.fasb.org/extlink&oid=6959260&loc=d3e187085-122770



Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 210

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.5-02.28,29)

-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682



Reference 5: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

-SubTopic 10

-Section 50

-Paragraph 2

-Subparagraph (c)(1)(iv)(2)

-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901



Reference 6: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 29, 30

-Article 5

+ Details

Name:	us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised
Namespace Prefix:	us-gaap_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	duration