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Quarterly Financial Data (Unaudited) (Details) (USD $)
In Thousands, except Per Share data, unless otherwise specified
 3 Months Ended 12 Months Ended
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2013
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Quarterly Financial Data (Unaudited) [Abstract]                      
Operating loss $ (3,285)us-gaap_OperatingIncomeLoss $ (5,054)us-gaap_OperatingIncomeLoss $ (5,904)us-gaap_OperatingIncomeLoss $ (5,059)us-gaap_OperatingIncomeLoss $ (5,526)us-gaap_OperatingIncomeLoss $ (6,702)us-gaap_OperatingIncomeLoss $ (10,587)us-gaap_OperatingIncomeLoss $ (10,202)us-gaap_OperatingIncomeLoss $ (19,304)us-gaap_OperatingIncomeLoss $ (33,019)us-gaap_OperatingIncomeLoss $ (53,871)us-gaap_OperatingIncomeLoss
Change in fair value of warrant liability, net 330us-gaap_FairValueAdjustmentOfWarrants 519us-gaap_FairValueAdjustmentOfWarrants 1,297us-gaap_FairValueAdjustmentOfWarrants (205)us-gaap_FairValueAdjustmentOfWarrants 410us-gaap_FairValueAdjustmentOfWarrants (497)us-gaap_FairValueAdjustmentOfWarrants 5,115us-gaap_FairValueAdjustmentOfWarrants (2,272)us-gaap_FairValueAdjustmentOfWarrants (1,942)us-gaap_FairValueAdjustmentOfWarrants (2,756)us-gaap_FairValueAdjustmentOfWarrants (2,159)us-gaap_FairValueAdjustmentOfWarrants
Net loss $ (2,945)us-gaap_NetIncomeLoss $ (4,558)us-gaap_NetIncomeLoss $ (4,600)us-gaap_NetIncomeLoss $ (5,278)us-gaap_NetIncomeLoss $ (4,792)us-gaap_NetIncomeLoss $ (7,206)us-gaap_NetIncomeLoss $ (5,482)us-gaap_NetIncomeLoss $ (12,845)us-gaap_NetIncomeLoss $ (17,381)us-gaap_NetIncomeLoss $ (30,324)us-gaap_NetIncomeLoss $ (51,868)us-gaap_NetIncomeLoss
Basic loss per share (in dollars per share) $ (0.31)us-gaap_EarningsPerShareBasic $ (0.48)us-gaap_EarningsPerShareBasic $ (0.49)us-gaap_EarningsPerShareBasic $ (0.57)us-gaap_EarningsPerShareBasic         $ (1.84)us-gaap_EarningsPerShareBasic [1] $ (4.81)us-gaap_EarningsPerShareBasic [1] $ (13.54)us-gaap_EarningsPerShareBasic [1]
Diluted loss per share (in dollars per share) $ (0.31)us-gaap_EarningsPerShareDiluted $ (0.48)us-gaap_EarningsPerShareDiluted $ (0.52)us-gaap_EarningsPerShareDiluted $ (0.57)us-gaap_EarningsPerShareDiluted         $ (1.84)us-gaap_EarningsPerShareDiluted [1] $ (5.10)us-gaap_EarningsPerShareDiluted [1] $ (13.54)us-gaap_EarningsPerShareDiluted [1]
Basic and diluted loss per share (in dollars per share)         $ (0.63)us-gaap_EarningsPerShareBasicAndDiluted $ (1.15)us-gaap_EarningsPerShareBasicAndDiluted $ (0.91)us-gaap_EarningsPerShareBasicAndDiluted $ (2.40)us-gaap_EarningsPerShareBasicAndDiluted      
[1] Reflects a one-for-sixteen (1:16) reverse stock split effected on April 8, 2014.