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Income Taxes - Income tax reconciliation (Details) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Provision for income taxes [Abstract] |  |  |
Income taxes using U.S federal statutory rate | $ (4,999,000) | $ (5,926,000) | $ (10,309,000)
Amortization of gain on IP migration | 767,000 | 767,000 | 781,000
State income taxes, net of federal benefit | 380,000 | 2,215,000 | (1,390,000)
Foreign rate differential | 920,000 | 1,069,000 | 2,761,000
Valuation allowance | 2,649,000 | 886,000 | 7,683,000
Derivative charge | (192,000) | (660,000) | (937,000)
Stock option exercises and cancellations | 674,000 | 1,748,000 | 1,589,000
Research and development costs | (199,000) | (125,000) | (1,090,000)
Other |  | 26,000 | 912,000
Total | $ 0 | $ 0 | $ 0

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- Definition The portion of the difference between total income tax expense or benefit as reported in the Income Statement and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to derivative costs. + References No definition available. + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to foreign income tax expense (benefit). + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=6907707&loc=d3e32698-109319 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 08 -Paragraph h -Subparagraph 1 -Article 4 + Details
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