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Stockholders' Equity - Assumptions Used to Determine Estimated Fair Value of Stock Options Granted (Details) - $ / shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Assumptions used to determine the fair value of stock options [Abstract]      
Weighted average grant date fair value (in dollars per share) $ 1.19 $ 1.78  
Stock Options [Member]      
Assumptions used to determine the fair value of stock options [Abstract]      
Weighted average risk-free interest rates (in hundredths) 1.82% 1.53% 1.30%
Weighted average expected volatility (in hundredths) 97.70% 96.68% 92.31%
Expected volatility (in hundredths) 97.70%    
Weighted average expected option term (in years) 5 years 1 month 24 days 4 years 6 months 5 years 7 months 28 days
Weighted average grant date fair value (in dollars per share) $ 0.89 $ 1.78 $ 17.41
Stock Options [Member] | Minimum [Member]      
Assumptions used to determine the fair value of stock options [Abstract]      
Expected volatility (in hundredths)   95.47% 86.16%
Stock Options [Member] | Maximum [Member]      
Assumptions used to determine the fair value of stock options [Abstract]      
Expected volatility (in hundredths)   98.14% 97.21%