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Quarterly Financial Data (Unaudited) (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Quarterly Financial Information Disclosure [Abstract]                      
Operating loss $ (4,229) $ (3,650) $ (3,623) $ (3,708) $ (3,285) $ (5,054) $ (5,904) $ (5,059) $ (15,210) $ (19,304) $ (33,019)
Change in fair value of warrant liability, net (850) 1,253 (48) 209 330 519 1,297 (205) (564) (1,942) (2,756)
Net loss $ (5,095) $ (2,422) $ (3,699) $ (3,488) $ (2,945) $ (4,558) $ (4,600) $ (5,278) $ (14,704) $ (17,381) $ (30,324)
Basic and diluted loss per share $ (0.23) $ (0.12) $ (0.30) $ (0.32)              
Basic loss per share         $ (0.31) $ (0.48) $ (0.49) $ (0.57) $ (0.91) [1] $ (1.84) [1] $ (4.81) [1]
Diluted loss per share         $ (0.31) $ (0.48) $ (0.52) $ (0.57) $ (0.91) [1] $ (1.84) [1] $ (5.10) [1]
[1] Reflects a one-for-sixteen (1:16) reverse stock split effected on April 8, 2014.