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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Cash flows from operating activities:      
Net loss $ (14,704) $ (17,381) $ (30,324)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock option compensation expense 349 391 174
Restricted stock compensation expense 308 100 117
Depreciation expense 617 958 1,126
Provision or inventory obsolescence 0 118 0
Loss on disposal of equipment 15 282 5
Warrant liability fair value adjustment (564) (1,942) (2,756)
Non-cash interest income (1) 0 (1)
Changes in assets and liabilities:      
(Increase) decrease in prepaid expenses and other assets 9 718 (235)
(Increase) decrease in accounts receivable (52) 161 (211)
(Increase) decrease in inventories (420) 237 391
(Decrease) increase in accounts payable and accrued expenses (1,757) 132 (2,445)
Increase (decrease) in other non-current liabilities (220) 674 57
Net cash used in operating activities (16,420) (15,552) (34,102)
Cash flows from investing activities:      
Purchase of property, plant and equipment (170) (44) (142)
Proceeds from sales of property, plant and equipment 180 37 0
Net cash provided by (used in) investing activities 10 (7) (142)
Cash flows from financing activities:      
Net proceeds from sale of stock and exercise of warrants 8,655 4,869 41,702
Net cash provided by financing activities 8,655 4,869 41,702
Foreign currency effects on cash and cash equivalents (107) (90) 65
Net increase (decrease) in cash and cash equivalents (7,862) (10,780) 7,523
Cash and cash equivalents:      
Beginning of period 20,469 31,249 23,726
End of period 12,607 20,469 31,249
Supplemental non-cash activities:      
Fair value of warrants issued 4,247 0 1,857
Fair value of warrants exercised $ 123 $ 143 $ 218