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Income Taxes - Income tax reconciliation (Details) - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015
Provision for income taxes [Abstract] |  |
Income taxes using U.S federal statutory rate | $ (6,110,000) | $ (4,999,000)
Loss of tax benefit of net operating loss carryforwards | 68,795,000 |
Loss of tax benefit of state net operating loss carryforwards | 13,891,000 |
Loss of tax benefit of tax credit carryforwards | 4,023,000 |
Amortization of gain on IP migration | 767,000 | 767,000
State income taxes, net of federal benefit | (2,576,000) | 380,000
Foreign rate differential | 1,141,000 | 920,000
Valuation allowance | (75,407,000) | 2,649,000
Derivative charge | (4,345,000) | (192,000)
Stock option exercises and cancellations | 53,000 | 674,000
Research and development costs | (250,000) | (199,000)
Other | 18,000 |
Total | $ 0 | $ 0

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- Definition The portion of the difference between total income tax expense or benefit as reported in the Income Statement and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to derivative costs. + References No definition available. + Details
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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32639-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Income Tax Expense (or Benefit) -URI http://asc.fasb.org/extlink&oid=6515339 + Details
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