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<!-- Creation Date      : 2017-03-28T21:00:14.1895937+00:00 -->
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<!-- Copyright (c) 2017 Donnelley Financial, LLC. All Rights Reserved. -->
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  <element id="dcth_WarrantsFebruaryTwoThousandAndFifteenMember" name="WarrantsFebruaryTwoThousandAndFifteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_SeriesBCommonStockWarrantsMember" name="SeriesBCommonStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_SeriesAAndBCommonStockWarrantsMember" name="SeriesAAndBCommonStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_WarrantsOctoberTwoThousandAndSixteenMember" name="WarrantsOctoberTwoThousandAndSixteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_GrossProceedsFromUnderwritingOffering" name="GrossProceedsFromUnderwritingOffering" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
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  <element id="dcth_RemainingOutstandingWarrantsExpired" name="RemainingOutstandingWarrantsExpired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="dcth_PercentageOfIncreaseInNumberOfWarrantSharesIssuableUponExercise" name="PercentageOfIncreaseInNumberOfWarrantSharesIssuableUponExercise" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="dcth_WarrantIssuedDescriptionUponExercise" name="WarrantIssuedDescriptionUponExercise" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_ClassOfWarrantOrRightPeriodFromWhichWarrantsOrRightsExercisable" name="ClassOfWarrantOrRightPeriodFromWhichWarrantsOrRightsExercisable" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="dcth_SecuritiesIssuableToRaiseCapitalAuthorizedAmount" name="SecuritiesIssuableToRaiseCapitalAuthorizedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="dcth_EntityPublicFloatPursuantToSECRegulations" name="EntityPublicFloatPursuantToSECRegulations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="dcth_StockIncentivePlan2004Member" name="StockIncentivePlan2004Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_StockIncentivePlan2009Member" name="StockIncentivePlan2009Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableExercisePricePerShare" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableExercisePricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
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  <element id="dcth_ClassOfWarrantOrRightExpiredInPeriod" name="ClassOfWarrantOrRightExpiredInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_WarrantsOutstandingRollForward" name="WarrantsOutstandingRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_ClassOfWarrantOrRightWeightedAverageExercisePriceExpirationsInPeriod" name="ClassOfWarrantOrRightWeightedAverageExercisePriceExpirationsInPeriod" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="dcth_ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_NumberOfInputsUsedForValuationOfWarrants" name="NumberOfInputsUsedForValuationOfWarrants" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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  <element id="dcth_WarrantsSeriesCJuneTwoThousandAndSixteenMember" name="WarrantsSeriesCJuneTwoThousandAndSixteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_WarrantsSeriesAJulyTwoThousandAndFifteenMember" name="WarrantsSeriesAJulyTwoThousandAndFifteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_WarrantsOctoberTwoThousandAndThirteenMember" name="WarrantsOctoberTwoThousandAndThirteenMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_ExpansionOptionAdditionalSquareFootageOfOfficeSpace" name="ExpansionOptionAdditionalSquareFootageOfOfficeSpace" type="num:areaItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="dcth_AdditionalSquareFootageOfOfficeSpaceLeasedUnderExerciseOfOptionRight" name="AdditionalSquareFootageOfOfficeSpaceLeasedUnderExerciseOfOptionRight" type="num:areaItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="dcth_OfficeSpaceAtEightOneZeroAvenueNewYorkNYMember" name="OfficeSpaceAtEightOneZeroAvenueNewYorkNYMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_OfficeSpaceInNewYorkNewYorkLeaseAmendmentMember" name="OfficeSpaceInNewYorkNewYorkLeaseAmendmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_OfficeSpaceInNewYorkNewYorkInitialLeaseAndLeaseAmendmentMember" name="OfficeSpaceInNewYorkNewYorkInitialLeaseAndLeaseAmendmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_ContractYearDomain" name="ContractYearDomain" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_Year2Member" name="Year2Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_Year3Member" name="Year3Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_Year4Member" name="Year4Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_Year5Member" name="Year5Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_YearsThereafterMember" name="YearsThereafterMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_Year6Through10Member" name="Year6Through10Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_DelcathSEuropeanHeadquartersLeaseAgreementMember" name="DelcathSEuropeanHeadquartersLeaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_OfficeSpaceAt1633BroadwayNewYorkNYMember" name="OfficeSpaceAt1633BroadwayNewYorkNYMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_ParkRoadLeaseAgreementMember" name="ParkRoadLeaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_DeliveryTimeFrameOfWrittenNoticeMinimum" name="DeliveryTimeFrameOfWrittenNoticeMinimum" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_LeaseExpirationMonthAndYear" name="LeaseExpirationMonthAndYear" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_LetterOfCreditAbstract" name="LetterOfCreditAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_MinimumLetterOfCreditAmountRequiredToBeMaintained" name="MinimumLetterOfCreditAmountRequiredToBeMaintained" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <element id="dcth_ExpireBetween2018And2036Member" name="ExpireBetween2018And2036Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_NewYorkCityMember" name="NewYorkCityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <element id="dcth_AccountingStandardsUpdate201609Member" name="AccountingStandardsUpdate201609Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
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  <element id="dcth_MinimumBidPricePerShareRequiredToRegainComplianceWithListingQualifications" name="MinimumBidPricePerShareRequiredToRegainComplianceWithListingQualifications" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <element id="dcth_StockMarketGrantedAdditionalPeriod" name="StockMarketGrantedAdditionalPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_StockMarketGrantedConsecutiveTradingPeriodPrecedingTermOfNotice" name="StockMarketGrantedConsecutiveTradingPeriodPrecedingTermOfNotice" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <element id="dcth_ConsecutiveBusinessDaysForClosingBidPriceOfCommonStock" name="ConsecutiveBusinessDaysForClosingBidPriceOfCommonStock" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
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</schema>
