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Stockholders' Equity - Summary of Warrant Activity (Details) - $ / shares | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Warrants outstanding [Roll Forward] |  |  |
Outstanding, beginning of period (in shares) | 1,128,688 | 53,134 |
Issued (in shares) | 7,031,929 | 1,091,844 |
Exercised (in shares) | (499,633) | (13,457) |
Expired (in shares) | (444,964) | (2,833) |
Outstanding, end of period (in shares) | 7,216,020 | 1,128,688 | 53,134
Warrants, Weighted Average Exercise Price [Roll Forward] |  |  |
Outstanding, beginning of period (in dollars per share) | $ 16.02 | $ 86.69 |
Issued (in dollars per share) | 4.80 | 12.80 |
Exercised (in dollars per share) | 2.75 | 13.12 |
Expired (in dollars per share) | 5.68 | 13.12 |
Outstanding, end of period (in dollars per share) | $ 5.20 | $ 16.02 | $ 86.69
Weighted average remaining life | 5 years 7 months 2 days | 2 years 1 month 28 days | 2 years 9 months 11 days
Minimum [Member] |  |  |
Warrants, Exercise Price per Share [Roll Forward] |  |  |
Outstanding, (in dollars per share) | $ 1.61 | $ 11.84 | $ 28.00
Maximum [Member] |  |  |
Warrants, Exercise Price per Share [Roll Forward] |  |  |
Outstanding, (in dollars per share) | $ 112.64 | $ 112.64 | $ 112.64

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