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Income Taxes - Income tax reconciliation (Details) - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Provision for income taxes [Abstract]    
Income taxes using U.S federal statutory rate $ (6,110,000) $ (4,999,000)
Loss of tax benefit of net operating loss carryforwards 68,795,000  
Loss of tax benefit of state net operating loss carryforwards 13,891,000  
Loss of tax benefit of tax credit carryforwards 4,023,000  
Amortization of gain on IP migration 767,000 767,000
State income taxes, net of federal benefit (2,576,000) 380,000
Foreign rate differential 1,141,000 920,000
Valuation allowance (75,407,000) 2,649,000
Derivative charge (4,345,000) (192,000)
Stock option exercises and cancellations 53,000 674,000
Research and development costs (250,000) (199,000)
Other 18,000  
Total $ 0 $ 0