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General - Additional Information (Details) |  |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Nov. 06, 2017 $ / shares shares | Jul. 21, 2016 $ / shares shares | Sep. 30, 2017 USD ($) $ / shares | Sep. 30, 2016 USD ($) | Sep. 30, 2017 USD ($) $ / shares | Sep. 30, 2016 USD ($) | Dec. 31, 2016 USD ($) $ / shares | Jun. 30, 2016 USD ($)
Class Of Stock [Line Items] |  |  |  |  |  |  |  |
Reverse stock split ratio |  | 0.0625 |  |  |  |  |  |
Number of fractional shares were issued in connection with the reverse stock split | shares |  | 0 |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  | $ 0.01 | $ 0.01 |  | $ 0.01 |  | $ 0.01 |
Net loss |  |  | $ 12,596,000 | $ 1,004,000 | $ 25,873,000 | $ 9,485,000 |  |
Net cash used in operating activities |  |  |  |  | 11,659,000 | $ 10,597,000 |  |
Accumulated deficit |  |  | 305,587,000 |  | 305,587,000 |  | $ 279,188,000 |
Senior Secured Convertible Notes [Member] |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |
Debt instrument, principal face amount |  |  | $ 11,437,000 |  | $ 11,437,000 |  |  | $ 35,000,000
Subsequent Event [Member] |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |
Reverse stock split ratio | 0.0029 |  |  |  |  |  |  |
Subsequent Event [Member] | OTCQB [Member] |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |
Reverse stock split ratio | 0.0029 |  |  |  |  |  |  |
Number of fractional shares were issued in connection with the reverse stock split | shares | 0 |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares | $ 0.01 |  |  |  |  |  |  |

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