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Stockholders' Equity - Stock and Warrant Issuances - Additional Information (Details) |  |  | 1 Months Ended | 2 Months Ended | 12 Months Ended |  |  |
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Oct. 10, 2017 shares | Apr. 02, 2017 USD ($) | Nov. 30, 2017 USD ($) Investor shares | Oct. 31, 2016 USD ($) shares | Jun. 30, 2016 USD ($) shares | Jul. 31, 2015 USD ($) shares | Feb. 28, 2015 USD ($) shares | Oct. 31, 2013 USD ($) shares | Dec. 31, 2017 Investor $ / shares shares | Dec. 31, 2017 USD ($) $ / shares shares | Dec. 31, 2016 USD ($) $ / shares shares | Dec. 31, 2015 USD ($) $ / shares shares | Jun. 06, 2016 USD ($) shares | Oct. 20, 2015 USD ($) | Dec. 31, 2014 $ / shares shares
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of common stock, net of expenses (in shares) |  |  |  | 1,215 |  | 1,670 | 440 | 234 |  |  |  |  |  |  |
Proceeds from issuance of private placement | $ |  |  |  | $ 1,200,000 |  |  | $ 2,600,000 | $ 7,500,000 |  |  |  |  |  |  |
Net proceeds from issuance of private placement | $ |  |  |  | $ 1,100,000 |  |  | $ 2,500,000 | $ 6,900,000 |  |  |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 7,005,952 | 7,005,952 | 20,616 | 3,224 |  |  | 152
Sale of units to underwriter |  |  |  |  |  | 1,670 |  |  |  |  |  |  |  |  |
Proceeds of common stock issued, net of related expenses | $ |  |  |  |  |  | $ 6,000,000 |  |  |  |  |  |  |  |  |
Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 39,424 | $ 39,424 | $ 39,424 | $ 39,424 |  |  | $ 39,424
Maximum offering and selling of stock and securities that entity make to raise capital | $ |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 71,800,000 |
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 2.45 | 2.45 | $ 563.50 | $ 4,144 |  |  | $ 9,800
Amendment to Restructuring Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase Common Stock | 127,551 |  |  |  |  |  |  |  | 127,551 |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 122.50 | $ 122.50 |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 5,000 | 5,000 |  |  |  |  |
Term period for warrants |  |  |  |  |  |  |  |  | 4 years 6 months |  |  |  |  |  |
Warrants exercised (in shares) |  |  |  |  |  |  |  |  | 122,551 |  |  |  |  |  |
Number of investors | Investor |  |  |  |  |  |  |  |  | 2 |  |  |  |  |  |
Warrants exercise price description |  |  |  |  |  |  |  |  |  | The warrants contain a cashless exercise provision that allows the holders to exercise each warrant for three shares of common stock. |  |  |  |  |
Shares issuable upon warrants exercised |  |  |  |  |  |  |  |  | 367,653 | 367,653 |  |  |  |  |
Securities Purchase Agreement [Member] | Warrant Repurchase Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate amount to be paid in exchange for cancellation of warrants | $ |  | $ 7,900,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Common Shares [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sale of common stock, net of expenses (in shares) |  |  |  |  |  |  |  |  |  |  | 1,223 | 2,109 |  |  |
Common shares and rights issued |  |  |  |  |  |  |  |  |  | 113,643,624 | 5,158 |  |  |  |
Senior Secured Convertible Notes [Member] | Securities Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt instrument, principal face amount | $ |  |  |  |  |  |  |  |  |  |  |  |  | $ 35,000,000 |  |
Senior Secured Convertible Notes [Member] | Rights [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares and rights issued |  |  |  |  |  |  |  |  |  | 108,900,000 |  |  |  |  |
Senior Secured Convertible Notes [Member] | Common Shares [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common shares and rights issued |  |  |  |  |  |  |  |  |  | 112,200,000 |  |  |  |  |
Series A Common Stock Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 49.00 | $ 49.00 |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 541,000,000 | 541,000,000 |  |  |  |  |
Warrants exercised (in shares) |  |  |  |  |  |  |  |  |  | 300 | 700 |  |  |  |
Net proceeds from exercise of warrants | $ |  |  |  |  |  |  |  |  |  | $ 15,000 | $ 400,000 |  |  |  |
Number of warrants converted |  |  |  |  |  | 1,253 |  |  |  |  | 399 |  |  |  |
Gross proceeds from underwriting offering | $ |  |  |  |  |  | $ 7,000,000 |  |  |  |  |  |  |  |  |
Warrants expiry period |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |
Series B Common Stock Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercised (in shares) |  |  |  |  |  |  |  |  |  |  | 399 |  |  |  |
Net proceeds from exercise of warrants | $ |  |  |  |  |  |  |  |  |  |  | $ 800,000 |  |  |  |
Number of warrants converted |  |  |  |  |  | 1,670,000,000 |  |  |  |  |  |  |  |  |
Remaining outstanding warrants expired |  |  |  |  |  |  |  |  |  |  | 1,271 |  |  |  |
Warrants expiration date |  |  |  |  |  |  |  |  |  | Jan. 29, 2016 |  |  |  |  |
Series A and B Common Stock Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of warrants issued | $ |  |  |  |  |  | $ 3,400,000 |  |  |  |  |  |  |  |  |
2013 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase Common Stock |  |  |  |  |  |  |  | 106 |  |  |  |  |  |  |
Value of warrants issued | $ |  |  |  |  |  |  |  | $ 1,900,000 |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 39,424 | $ 39,424 |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 106 | 106 |  |  |  |  |
Term period for warrants |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |
February 2015 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase Common Stock |  |  |  |  |  |  | 197 |  |  |  |  |  |  |  |
Value of warrants issued | $ |  |  |  |  |  |  | $ 800,000 |  |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 49.00 | $ 49.00 |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 92 | 92 |  |  |  |  |
Term period for warrants |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |
Warrants exercised (in shares) |  |  |  |  |  |  |  |  |  |  | 114 |  |  |  |
Net proceeds from exercise of warrants | $ |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |
Series C Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Value of warrants issued | $ |  |  |  |  | $ 27,800,000 |  |  |  |  |  |  |  |  |  |
Aggregate amount to be paid in exchange for cancellation of warrants | $ |  |  |  |  |  |  |  |  |  | $ 7,876,000 | $ 0 | $ 0 |  |  |
Series C Warrants [Member] | Securities Purchase Agreement [Member] | Warrant Repurchase Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate amount to be paid in exchange for cancellation of warrants | $ |  |  |  |  | $ 7,900,000 |  |  |  |  |  |  |  |  |  |
Series C Warrants [Member] | Senior Secured Convertible Notes [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants converted |  |  |  |  | 19,368 |  |  |  |  |  |  |  |  |  |
Debt instrument, principal face amount | $ |  |  |  |  | $ 35,000,000 |  |  |  |  |  |  |  |  |  |
Series C Warrants [Member] | Senior Secured Convertible Notes [Member] | Securities Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issuable upon warrants exercised |  |  |  |  |  |  |  |  |  |  |  |  | 20,000 |  |
October 2016 Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase Common Stock |  |  |  | 425 |  |  |  |  |  |  |  |  |  |  |
Value of warrants issued | $ |  |  |  | $ 300,000 |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 49.00 | $ 49.00 |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 225 | 225 |  |  |  |  |
Term period for warrants |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |
Warrants exercised (in shares) |  |  |  |  |  |  |  |  |  |  | 200 |  |  |  |
Net proceeds from exercise of warrants | $ |  |  |  |  |  |  |  |  |  |  | $ 100,000 |  |  |  |
November 2017 Warrants [Member] | Exchange Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders Equity Note [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants issued to purchase Common Stock |  |  | 7,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Value of warrants issued | $ |  |  | $ 14,400,000 |  |  |  |  |  |  |  |  |  |  |  |
Warrants exercisable per share price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  | $ 2.45 | $ 2.45 |  |  |  |  |
Number of warrants outstanding (in shares) |  |  |  |  |  |  |  |  | 7,000,000 | 7,000,000 |  |  |  |  |
Term period for warrants |  |  |  |  |  |  |  |  |  | 5 years |  |  |  |  |
Number of investors | Investor |  |  | 2 |  |  |  |  |  |  |  |  |  |  |  |

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