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Stockholders' Equity - Summary of Warrant Activity (Details) - $ / shares | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Warrants outstanding [Roll Forward] |  |  |  |
Outstanding, beginning of period (in shares) | 20,616 | 3,224 | 152 |
Issued (in shares) | 7,127,551 | 20,091 | 3,120 |
Exercised (in shares) | (122,848) | (1,428) | (39) |
Expired (in shares) | (19,367) | (1,271) | (8) |
Outstanding, end of period (in shares) | 7,005,952 | 20,616 | 3,224 | 152
Warrants, Weighted Average Exercise Price [Roll Forward] |  |  |  |
Outstanding, beginning of period (in dollars per share) | $ 1,820.00 | $ 5,607.33 | $ 30,341.76 |
Issued (in dollars per share) | 4.60 | 1,680.00 | 4,480.00 |
Exercised (in dollars per share) | 8.44 | 963.00 | 4,592.00 |
Expired (in dollars per share) | 1,690.50 | 1,988.00 | 4,592.00 |
Outstanding, end of period (in dollars per share) | $ 3.14 | $ 1,820.00 | $ 5,607.33 | $ 30,341.76
Weighted average remaining life | 4 years 10 months 17 days | 5 years 7 months 2 days | 2 years 1 month 28 days | 2 years 9 months 11 days
Minimum [Member] |  |  |  |
Warrants, Exercise Price per Share [Roll Forward] |  |  |  |
Outstanding, (in dollars per share) | $ 2.45 | $ 563.50 | $ 4,144 | $ 9,800
Maximum [Member] |  |  |  |
Warrants, Exercise Price per Share [Roll Forward] |  |  |  |
Outstanding, (in dollars per share) | $ 39,424 | $ 39,424 | $ 39,424 | $ 39,424

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