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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Cash flows from operating activities:    
Net loss $ (8,353) $ (25,873)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock option compensation (income) expense (40) 48
Restricted stock compensation expense 35 84
Depreciation expense 342 198
Loss on disposal of equipment 0 20
Warrant liability fair value adjustment (18,407) (1,227)
Gain on warrant extinguishment 0 (9,613)
Non-cash interest income (2) 16
Deferred revenue 0 (30)
Debt discount amortization 3,381 20,315
Loss on issuance of financial instrument 2,826 0
Loss on debt extinguishment 1,123 2,952
Changes in assets and liabilities:    
Prepaid expenses and other assets 171 276
Accounts receivable (60) (94)
Inventories 289 (338)
Accounts payable and accrued expenses 5,662 1,767
Other non-current liabilities 139 (160)
Net cash used in operating activities (12,894) (11,659)
Cash flows from investing activities:    
Purchase of property, plant and equipment (59) (372)
Net cash used in investing activities (59) (372)
Cash flows from financing activities:    
Expenses from the release of restricted cash 0 (788)
Net proceeds from sale of Series B and Series C preferred shares 0 2,278
Net proceeds from convertible note debt financing 5,727 0
Net proceeds from sale of common stock and pre-funded warrants 11,797 15
Net cash provided by financing activities 17,524 (8,731)
Foreign currency effects on cash, cash equivalents and restricted cash 80 (77)
Net decrease in cash, cash equivalents and restricted cash 4,651 (20,839)
Cash, cash equivalents and restricted cash:    
Beginning of period 5,324 31,696
End of period 9,975 10,857
Supplemental non-cash financing activities:    
Conversion of convertible notes to common stock 0 26,199
Fair value of warrants issued 28,539 0
Fair value of warrants exercised 0 19
Series A and Series B Preferred Shares [Member]    
Cash flows from financing activities:    
Redemption of Series A and Series B preferred shares 0 (2,360)
Series C Warrants [Member]    
Cash flows from financing activities:    
Cash paid to extinguish of Series C Warrants $ 0 $ (7,876)