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Stockholders' Equity - Summary of Warrant Activity (Detail) - $ / shares
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Warrants outstanding [Roll Forward]      
Outstanding, beginning of period (in shares) 1,128,688 53,134  
Issued (in shares) 7,031,929 1,091,844  
Exercised (in shares) (499,633) (13,457)  
Expired (in shares) (444,964) (2,833)  
Outstanding, end of period (in shares) 7,216,020 1,128,688 53,134
Warrants, Weighted Average Exercise Price [Roll Forward]      
Weighted average remaining life 5 years 7 months 2 days 2 years 1 month 28 days 2 years 9 months 11 days
Outstanding, beginning of period (in dollars per share) $ 16.02 $ 86.69  
Issued (in dollars per share) 4.80 12.80  
Exercised (in dollars per share) 2.75 13.12  
Expired (in dollars per share) 5.68 13.12  
Outstanding, end of period (in dollars per share) 5.20 16.02 $ 86.69
Minimum [Member]      
Warrants, Exercise Price per Share [Roll Forward]      
Outstanding, (in dollars per share) 1.61 11.84 28
Maximum [Member]      
Warrants, Exercise Price per Share [Roll Forward]      
Outstanding, (in dollars per share) $ 112.64 $ 112.64 $ 112.64