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Income Taxes - Income tax reconciliation (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Provision for income taxes [Abstract]    
Income taxes using U.S federal statutory rate $ (6,110) $ (4,999)
Loss of tax benefit of net operating loss carryforwards 68,795  
Loss of tax benefit of state net operating loss carryforwards 13,891  
Loss of tax benefit of tax credit carryforwards 4,023  
Amortization of gain on IP migration 767 767
State income taxes, net of federal benefit (2,576) 380
Foreign rate differential 1,141 920
Valuation allowance (75,407) 2,649
Derivative charge (4,345) (192)
Stock option exercises and cancellations 53 674
Research and development costs (250) (199)
Other 18  
Total $ 0 $ 0