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Income Taxes - Significant Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | --- | ---
Deferred tax assets: |  |  |
Employee compensation accruals | $ 292 | $ 1,386 | $ 1,279
Accrued liabilities | 353 | 343 | 633
Research tax credits | 17 | 22 | 3,796
Other | 34 | 55 | 66
Net operating losses | 5,289 | 6,194 | 77,906
Total deferred tax assets | 5,985 | 8,000 | 83,680
Deferred tax liabilities: |  |  |
Beneficial conversion feature |  | 906 |
Other | 13 |  |
Total deferred tax liabilities | 13 | 906 | 0
Valuation allowance | 5,972 | 7,094 | 83,680
Net deferred tax assets | $ 0 | $ 0 | $ 0

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