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General - Additional Information (Detail) $ / shares in Units, $ in Thousands |  |  |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | ---
May 02, 2018 $ / shares shares | Nov. 06, 2017 $ / shares shares | Jul. 21, 2016 $ / shares shares | Mar. 31, 2018 USD ($) Contract $ / shares | Dec. 31, 2017 USD ($) $ / shares | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) $ / shares | Sep. 30, 2016 USD ($) | Jun. 30, 2016 USD ($) | Mar. 31, 2016 USD ($) | Dec. 31, 2017 USD ($) $ / shares | Dec. 31, 2016 USD ($) $ / shares | Dec. 31, 2015 USD ($)
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | $ |  |  |  | $ (7,187) | $ 19,246 | $ 12,596 | $ 1,943 | $ 11,332 | $ 8,486 | $ 1,004 | $ 6,667 | $ 1,813 | $ 45,117 | $ 17,971 | $ 14,704
Net cash used in operating activities | $ |  |  |  |  |  |  |  |  |  |  |  |  | 15,398 |  |
Accumulated deficit | $ |  |  |  | $ 317,645 | $ 324,832 |  |  |  | $ 279,188 |  |  |  | $ 324,832 | $ 279,188 |
Reverse stock split |  | 1:350 |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split ratio |  | 0.0029 | 0.0625 |  |  |  |  |  |  |  |  |  |  |  |
Number of fractional shares were issued in connected with the reverse stock split | shares |  |  | 0 |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  |  | $ 0.01 | $ 0.01 | $ 0.01 |  |  |  | $ 0.01 |  |  |  | $ 0.01 | $ 0.01 |
Number of distribution contracts with Turkish distributor | Contract |  |  |  | 1 |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split | 1:500 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split ratio | 0.002 |  |  |  |  |  |  |  |  |  |  |  |  |  |
OTCQB [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split ratio |  | 0.0029 |  |  |  |  |  |  |  |  |  |  |  |  |
Number of fractional shares were issued in connected with the reverse stock split | shares |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares |  | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |
OTCQB [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class Of Stock [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split | 1:500 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split ratio | 0.0020 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number of fractional shares were issued in connected with the reverse stock split | shares | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ / shares | $ 0.01 |  |  |  |  |  |  |  |  |  |  |  |  |  |

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