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Income Taxes - Income tax reconciliation (Detail) - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Provision for income taxes [Abstract]      
Income taxes using U.S federal statutory rate $ (15,340,000) $ (6,110,000) $ (4,999,000)
Tax Cuts and Jobs Act 143,000    
Nondeductible interest 6,912,000    
Loss on extinguishment of debt 10,174,000    
Loss of tax benefit of federal net operating loss carryforwards 5,067,000 68,795,000  
Loss of tax benefit of state net operating loss carryforwards 1,373,000 13,891,000  
Loss of tax benefit of federal tax credit carryforwards 324,000 4,023,000  
Amortization of gain on IP migration 767,000 767,000 767,000
State income taxes, net of federal benefit (1,339,000) (2,576,000) 380,000
Foreign rate differential 1,196,000 1,141,000 920,000
Valuation allowance (1,423,000) (75,407,000) 2,649,000
Derivative charge (8,403,000) (4,345,000) (192,000)
Stock option exercises and cancellations 841,000 53,000 674,000
Research and development costs (295,000) (250,000) (199,000)
Other 3,000 18,000  
Total $ 0 $ 0 $ 0