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Income Taxes - Income tax reconciliation (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Provision for income taxes [Abstract] |  |  |
Income taxes using U.S federal statutory rate | $ (15,340,000) | $ (6,110,000) | $ (4,999,000)
Tax Cuts and Jobs Act | 143,000 |  |
Nondeductible interest | 6,912,000 |  |
Loss on extinguishment of debt | 10,174,000 |  |
Loss of tax benefit of federal net operating loss carryforwards | 5,067,000 | 68,795,000 |
Loss of tax benefit of state net operating loss carryforwards | 1,373,000 | 13,891,000 |
Loss of tax benefit of federal tax credit carryforwards | 324,000 | 4,023,000 |
Amortization of gain on IP migration | 767,000 | 767,000 | 767,000
State income taxes, net of federal benefit | (1,339,000) | (2,576,000) | 380,000
Foreign rate differential | 1,196,000 | 1,141,000 | 920,000
Valuation allowance | (1,423,000) | (75,407,000) | 2,649,000
Derivative charge | (8,403,000) | (4,345,000) | (192,000)
Stock option exercises and cancellations | 841,000 | 53,000 | 674,000
Research and development costs | (295,000) | (250,000) | (199,000)
Other | 3,000 | 18,000 |
Total | $ 0 | $ 0 | $ 0

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- Definition The portion of the difference between total income tax expense or benefit as reported in the Income Statement and the expected income tax expense or benefit computed by applying the domestic federal statutory income tax rates to pretax income from continuing operations attributable to derivative costs. + References No definition available. + Details
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