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Quarterly Financial Data (Unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |
Revenue | $ 704 | $ 684 | $ 584 | $ 743 | $ 676 | $ 435 | $ 511 | $ 370 | $ 2,715 | $ 1,992 | $ 1,747
Costs and expenses | 5,254 | 5,139 | 5,050 | 4,736 | 4,882 | 5,047 | 4,232 | 3,721 | 20,179 | 17,882 | 16,495
Operating loss | (4,725) | (4,627) | (4,601) | (4,212) | (4,383) | (4,724) | (3,871) | (3,462) | (18,165) | (16,440) | (15,210)
Net loss | $ (19,246) | $ (12,596) | $ (1,943) | $ (11,332) | $ (8,486) | $ (1,004) | $ (6,667) | $ (1,813) | $ (45,117) | $ (17,971) | $ (14,704)
Basic loss per share | $ (0.75) | $ (9.36) | $ (3.50) | $ (87.50) | $ (1,292.02) | $ (230.99) | $ (1,543.50) | $ (437.50) |  |  |

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