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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Statement [Abstract]      
Revenue $ 2,715 $ 1,992 $ 1,747
Cost of goods sold (701) (550) (462)
Gross profit 2,014 1,442 1,285
Operating expenses:      
Selling, general and administrative expenses 9,684 9,434 10,009
Research and development expenses 10,495 8,448 6,486
Total operating expenses 20,179 17,882 16,495
Operating loss (18,165) (16,440) (15,210)
Change in fair value of the warrant liability, net 15,103 12,780 564
Gain on warrant extinguishment 9,613 0 0
Loss on debt settlements and extinguishments (29,924) 0 0
Interest expense (21,703) (14,328) (67)
Other income (expense) (41) 17 9
Net loss (45,117) (17,971) (14,704)
Other comprehensive loss:      
Foreign currency translation adjustments 83 (33) (28)
Comprehensive loss $ (45,034) $ (18,004) $ (14,732)
Common share data:      
Basic and diluted loss per share [1] $ (6.50) $ (3,707) $ (5,096)
Weighted average number of basic and diluted shares outstanding [1] 7,019,316 4,847 2,887
[1] reflects a one-for-sixteen (1:16) reverse stock split effected on July 21, 2016 and a one-for-three hundred and fifty (1:350) reverse stock split effected on November 6, 2017.