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Stockholders' Equity - Stock and Warrant Issuances - Additional Information (Details)
 1 Months Ended 2 Months Ended 12 Months Ended
Oct. 10, 2017
shares
Apr. 02, 2017
USD ($)
Nov. 30, 2017
USD ($)
Investor
shares
Oct. 31, 2016
USD ($)
shares
Jun. 30, 2016
USD ($)
shares
Jul. 31, 2015
USD ($)
shares
Feb. 28, 2015
USD ($)
shares
Oct. 31, 2013
USD ($)
shares
Dec. 31, 2017
Investor
$ / shares
shares
Dec. 31, 2017
USD ($)
$ / shares
shares
Dec. 31, 2016
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
$ / shares
shares
Jun. 06, 2016
USD ($)
shares
Oct. 20, 2015
USD ($)
Dec. 31, 2014
$ / shares
shares
Stockholders Equity Note [Line Items]                              
Sale of common stock, net of expenses (in shares)       1,215   1,670 440 234              
Proceeds from issuance of private placement | $       $ 1,200,000     $ 2,600,000 $ 7,500,000              
Net proceeds from issuance of private placement | $       $ 1,100,000     $ 2,500,000 $ 6,900,000              
Number of warrants outstanding (in shares)                 7,005,952 7,005,952 20,616 3,224     152
Sale of units to underwriter           1,670                  
Proceeds of common stock issued, net of related expenses | $           $ 6,000,000                  
Maximum [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 39,424 $ 39,424 $ 39,424 $ 39,424     $ 39,424
Maximum offering and selling of stock and securities that entity make to raise capital | $                           $ 71,800,000  
Minimum [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 2.45 2.45 $ 563.50 $ 4,144     $ 9,800
Amendment to Restructuring Agreement [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants issued to purchase Common Stock 127,551               127,551            
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 122.50 $ 122.50          
Number of warrants outstanding (in shares)                 5,000 5,000          
Term period for warrants                 4 years 6 months            
Warrants exercised (in shares)                 122,551            
Number of investors | Investor                 2            
Warrants exercise price description                   The warrants contain a cashless exercise provision that allows the holders to exercise each warrant for three shares of common stock.          
Shares issuable upon warrants exercised                 367,653 367,653          
Securities Purchase Agreement [Member] | Warrant Repurchase Agreements [Member]                              
Stockholders Equity Note [Line Items]                              
Aggregate amount to be paid in exchange for cancellation of warrants | $   $ 7,900,000                          
Common Shares [Member]                              
Stockholders Equity Note [Line Items]                              
Sale of common stock, net of expenses (in shares)                     1,223 2,109      
Common shares and rights issued                   113,643,624 5,158        
Senior Secured Convertible Notes [Member] | Securities Purchase Agreement [Member]                              
Stockholders Equity Note [Line Items]                              
Debt instrument, principal face amount | $                         $ 35,000,000    
Senior Secured Convertible Notes [Member] | Rights [Member]                              
Stockholders Equity Note [Line Items]                              
Common shares and rights issued                   108,900,000          
Senior Secured Convertible Notes [Member] | Common Shares [Member]                              
Stockholders Equity Note [Line Items]                              
Common shares and rights issued                   112,200,000          
Series A Common Stock Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 49.00 $ 49.00          
Number of warrants outstanding (in shares)                 541,000,000 541,000,000          
Warrants exercised (in shares)                   300 700        
Net proceeds from exercise of warrants | $                   $ 15,000 $ 400,000        
Number of warrants converted           1,253         399        
Gross proceeds from underwriting offering | $           $ 7,000,000                  
Warrants expiry period                   5 years          
Series B Common Stock Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants exercised (in shares)                     399        
Net proceeds from exercise of warrants | $                     $ 800,000        
Number of warrants converted           1,670,000,000                  
Remaining outstanding warrants expired                     1,271        
Warrants expiration date                   Jan. 29, 2016          
Series A and B Common Stock Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Value of warrants issued | $           $ 3,400,000                  
2013 Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants issued to purchase Common Stock               106              
Value of warrants issued | $               $ 1,900,000              
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 39,424 $ 39,424          
Number of warrants outstanding (in shares)                 106 106          
Term period for warrants                   5 years          
February 2015 Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants issued to purchase Common Stock             197                
Value of warrants issued | $             $ 800,000                
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 49.00 $ 49.00          
Number of warrants outstanding (in shares)                 92 92          
Term period for warrants                   5 years          
Warrants exercised (in shares)                     114        
Net proceeds from exercise of warrants | $                     $ 100,000        
Series C Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Value of warrants issued | $         $ 27,800,000                    
Aggregate amount to be paid in exchange for cancellation of warrants | $                   $ 7,876,000 $ 0 $ 0      
Series C Warrants [Member] | Securities Purchase Agreement [Member] | Warrant Repurchase Agreements [Member]                              
Stockholders Equity Note [Line Items]                              
Aggregate amount to be paid in exchange for cancellation of warrants | $         $ 7,900,000                    
Series C Warrants [Member] | Senior Secured Convertible Notes [Member]                              
Stockholders Equity Note [Line Items]                              
Number of warrants converted         19,368                    
Debt instrument, principal face amount | $         $ 35,000,000                    
Series C Warrants [Member] | Senior Secured Convertible Notes [Member] | Securities Purchase Agreement [Member]                              
Stockholders Equity Note [Line Items]                              
Shares issuable upon warrants exercised                         20,000    
October 2016 Warrants [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants issued to purchase Common Stock       425                      
Value of warrants issued | $       $ 300,000                      
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 49.00 $ 49.00          
Number of warrants outstanding (in shares)                 225 225          
Term period for warrants                   5 years          
Warrants exercised (in shares)                     200        
Net proceeds from exercise of warrants | $                     $ 100,000        
November 2017 Warrants [Member] | Exchange Agreement [Member]                              
Stockholders Equity Note [Line Items]                              
Warrants issued to purchase Common Stock     7,000,000                        
Value of warrants issued | $     $ 14,400,000                        
Warrants exercisable per share price (in dollars per share) | $ / shares                 $ 2.45 $ 2.45          
Number of warrants outstanding (in shares)                 7,000,000 7,000,000          
Term period for warrants                   5 years          
Number of investors | Investor     2