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Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands		12 Months Ended
		Dec. 31, 2018	Dec. 31, 2017
Cost of goods sold		$ (1,009)	$ (701)
Gross profit		2,398	2,014
Operating expenses:
Research and development expenses		19,650	10,495
Selling, general and administrative expenses		9,819	9,684
Total operating expenses		29,469	20,179
Operating loss		(27,071)	(18,165)
Change in fair value of the warrant liability, net		19,706	15,103
Gain on warrant extinguishment		0	9,613
Loss on debt extinguishment		(1,123)	(29,924)
Loss on issuance of financial instrument		(2,826)	0
Interest expense		(7,959)	(21,703)
Other income (expense)		51	(41)
Net loss		(19,222)	(45,117)
Other comprehensive loss:
Foreign currency translation adjustments		8	83
Comprehensive loss		$ (19,214)	$ (45,034)
Common share data:
Basic and diluted loss per share	[1]	$ (0.72)	$ (3,250)
Weighted average number of basic and diluted shares outstanding	[1]	26,705,375	14,039
Product Revenue [Member]
Revenue		$ 3,378	$ 2,715
Other Revenue [Member]
Revenue		$ 29
[1] reflects a one-for-three hundred and fifty (1:350) reverse stock split effected on November 6, 2017 and a one-for-five hundred (1:500) reverse stock split effected on May 2, 2018.

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