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Convertible Notes Payable - Additional Information (Details) - USD ($) $ / shares in Units, shares in Millions	1 Months Ended			12 Months Ended
	Aug. 31, 2018	Jul. 31, 2018	Jun. 30, 2018	Dec. 31, 2018	Dec. 31, 2017	Sep. 21, 2018	Dec. 31, 2016
Debt Instrument [Line Items]
Debt instrument, principal face amount				$ 4,500,000
Exercise price of warrants				$ 0.22	$ 1,569		$ 910,000
Debt discount on senior notes				$ 2,500,000
Loss on issuance of financial instrument				2,826,000	$ 0
Fair value of warrants being reclassified from liability to equity				4,210,000
Loss on debt extinguishment				0	$ (9,613,000)
Notes payable maturity amount				$ 2,000,000
Minimum [Member]
Debt Instrument [Line Items]
Exercise price of warrants				$ 0.01	$ 1,225		281,750
Maximum [Member]
Debt Instrument [Line Items]
Exercise price of warrants				10.00	$ 19,712,000		$ 19,712,000
June 2018 Series D Warrants [Member]
Debt Instrument [Line Items]
Shares issuable upon warrants exercised			4.2
Warrants expiration period			5 years
Warrants value			$ 5,100,000
Debt discount on senior notes			2,300,000
Loss on issuance of financial instrument			$ 2,800,000
June 2018 Series D Warrants [Member] | Minimum [Member]
Debt Instrument [Line Items]
Exercise price of warrants			$ 1.75
June 2018 Series D Warrants [Member] | Maximum [Member]
Debt Instrument [Line Items]
Exercise price of warrants			$ 4.00
June 2018 Pre-Funded Series D Warrants [Member]
Debt Instrument [Line Items]
Shares issuable upon warrants exercised	22.2		65.0
Exercise price of warrants			$ 0.01
Warrants expiration period			5 years
Warrants exercisable period		Jul. 20, 2018
Fair value of warrants being reclassified from liability to equity		$ 4,200,000
June 2018 Pre-Funded Series D Warrants [Member] | Securities Purchase Agreement [Member]
Debt Instrument [Line Items]
Shares issuable upon warrants exercised			13.0
June Two Thousand Eighteen and July Two Thousand Eighteen Notes [Member]
Debt Instrument [Line Items]
Debt instrument, conversion price	$ 1.75
Percentage of subsequent financings used to repayment of notes payable	50.00%
Minimum percentage of change in cash flows	10.00%
Loss on debt extinguishment	$ 1,100,000
July Two Thousand Eighteen Pre Funded Series D Warrants
Debt Instrument [Line Items]
Shares issuable upon warrants exercised	15.8
July Two Thousand Eighteen Pre Funded Series D Warrants | Second Securities Purchase Agreement [Member]
Debt Instrument [Line Items]
Shares issuable upon warrants exercised		9.2
Senior Secured Convertible Notes
Debt Instrument [Line Items]
Interest rate						8.00%
Debt instrument, principal face amount						$ 9,400,000
Debt instrument, conversion price				$ 1.75
Debt instrument maturity start date				Dec. 31, 2018
Debt instrument maturity end date				Mar. 31, 2021
August 2018 Convertible Note [Member]
Debt Instrument [Line Items]
Notes payable maturity amount	$ 2,500

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