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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Cash flows from operating activities:    
Net loss $ (19,222) $ (45,117)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock option compensation expense (40) 50
Restricted stock compensation expense 98 79
Depreciation expense 444 310
Loss on disposal of equipment 0 18
Warrant liability fair value adjustment (19,706) (15,103)
Gain on warrant extinguishment 0 (9,613)
Non-cash interest income (1) (1)
Interest expense accrued related to convertible notes 402 0
Debt discount and deferred finance costs amortization 7,572 21,544
Loss on issuance of financial instrument 2,826 0
Loss on debt settlements and extinguishments 1,123 29,924
Changes in assets and liabilities:    
Prepaid expenses and other assets (218) 7
Accounts receivable (293) 108
Inventories 385 (543)
Accounts payable and accrued expenses 8,163 3,180
Deferred revenue 3,503 (32)
Other non-current liabilities 232 (209)
Net cash used in operating activities (14,732) (15,398)
Cash flows from investing activities:    
Purchase of property, plant and equipment (76) (524)
Net cash (used in) provided by investing activities (76) (524)
Cash flows from financing activities:    
Expenses from the release of restricted cash 0 (1,212)
Cash paid pursuant to Exchange Agreement 0 (804)
Net proceeds from convertible note debt financing 5,664 0
Net proceeds from sale of stock 10,917 15
Net proceeds from exercise of warrants 520 0
Repayment of convertible note debt (4,870) 0
Net cash provided by (used in) financing activities 13,236 (10,517)
Foreign currency effects on cash, cash equivalents and restricted cash (174) 67
Net decrease in cash, cash equivalents and restricted cash (1,746) (26,372)
Cash, cash equivalents and restricted cash:    
Beginning of period 5,324 31,696
End of period 3,578 5,324
Supplemental non-cash activities:    
Conversion of convertible notes 0 40,121
Fair value of warrants issued 28,539 16,953
Cashless exercise of warrants 0 2,537
Deemed dividend 0 527
Fair value of warrants exercised for cash 0 19
Series B and Series C Preferred Shares [Member]    
Cash flows from financing activities:    
Net proceeds from sale of preferred shares 0 2,310
Series A and Series B Preferred Shares [Member]    
Cash flows from financing activities:    
Cash paid to redeem preferred shares 0 (2,360)
Series C Preferred Shares [Member]    
Cash flows from financing activities:    
Cash paid to redeem preferred shares 0 (590)
Series D Preferred Shares [Member]    
Cash flows from financing activities:    
Net proceeds from sale of preferred shares 1,005 0
Series C Warrants [Member]    
Cash flows from financing activities:    
Cash paid to extinguish of Series C Warrants $ 0 $ (7,876)