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Summary of Significant Accounting Policies - Summary of Reconciliation of Weighted Average Shares Outstanding Calculation (Details) - shares | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2019 | Jun. 30, 2019 | Dec. 31, 2018 | Dec. 31, 2017 | [1]
Accounting Policies [Abstract] |  |  |  |  |
Weighted average shares issued | 17,910,886 | 18,676,912 | 2,738,944 |  |
Weighted average pre-funded warrants | 53,392,478 | 53,392,478 | 23,966,431 |  |
Weighted average shares outstanding | 71,303,364 | 72,069,390 | 26,705,375 | [1] | 14,039
[1] | reflects a one-for-three hundred and fifty (1:350) reverse stock split effected on November 6, 2017 and a one-for-five hundred (1:500) reverse stock split effected on May 2, 2018.

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- Definition Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS). + References No definition available. + Details
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