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Convertible Notes Payable - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Aug. 31, 2018 | Jul. 31, 2018 | Jun. 30, 2018 | Sep. 30, 2019 | Sep. 30, 2019 | Sep. 30, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Sep. 21, 2018 | Dec. 31, 2016
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, principal face amount |  |  |  |  |  |  | $ 4,500,000 |  |  |
Debt discount on senior notes |  |  |  |  |  |  | 2,500,000 |  |  |
Loss on issuance of financial instrument |  |  |  | $ 1,714,000 | $ 1,721,000 | $ 2,826,000 | 2,826,000 | $ 0 |  |
Fair value of warrants being reclassified from liability to equity |  |  |  |  | 11,000 |  | 4,210,000 |  |  |
Loss on debt extinguishment |  |  |  |  | $ 0 | $ 1,123,000 | 0 | $ (9,613,000) |  |
Notes payable maturity amount |  |  |  |  |  |  | $ 2,000,000 |  |  |
Minimum [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  | $ 7.00 | $ 7.00 |  | $ 7.00 | $ 857,500 |  | $ 197,225,000
Maximum [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  |  | $ 42.00 | $ 42.00 |  | 7,000 | $ 13,798,400,000 |  | $ 13,798,400,000
June 2018 Series D Warrants [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of common shares issuable on cancellation of warrants |  |  | 6,005 |  |  |  |  |  |  |
Warrants expiration period |  |  | 5 years |  |  |  |  |  |  |
Warrants value |  |  | $ 5,100,000 |  |  |  |  |  |  |
Debt discount on senior notes |  |  | 2,300,000 |  |  |  |  |  |  |
Loss on issuance of financial instrument |  |  | $ 2,800,000 |  |  |  |  |  |  |
June 2018 Series D Warrants [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  | $ 1,225 |  |  |  |  |  |  |
June 2018 Series D Warrants [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Exercise price of warrants |  |  | $ 2,800 |  |  |  |  |  |  |
June 2018 Pre-Funded Series D Warrants [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of common shares issuable on cancellation of warrants | 31,724 |  | 100,000 |  |  |  |  |  |  |
Exercise price of warrants |  |  | $ 7.00 |  |  |  |  |  |  |
Warrants expiration period |  |  | 5 years |  |  |  |  |  |  |
Warrants exercisable period |  | Jul. 20, 2018 |  |  |  |  |  |  |  |
Fair value of warrants being reclassified from liability to equity |  | $ 4,200,000 |  |  |  |  |  |  |  |
June 2018 Pre-Funded Series D Warrants [Member] | Securities Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of common shares issuable on cancellation of warrants |  |  | 18,506 |  |  |  |  |  |  |
June Two Thousand Eighteen and July Two Thousand Eighteen Notes [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Debt instrument, conversion price | $ 1,225 |  |  |  |  |  |  |  |  |
Percentage of subsequent financings used to repayment of notes payable | 50.00% |  |  |  |  |  |  |  |  |
Minimum percentage of change in cash flows | 10.00% |  |  |  |  |  |  |  |  |
Loss on debt extinguishment | $ 1,100,000 |  |  |  |  |  |  |  |  |
July Two Thousand Eighteen Pre Funded Series D Warrants |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of common shares issuable on cancellation of warrants | 22,640 |  |  |  |  |  |  |  |  |
July Two Thousand Eighteen Pre Funded Series D Warrants | Second Securities Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Number of common shares issuable on cancellation of warrants |  | 13,207 |  |  |  |  |  |  |  |
Senior Secured Convertible Notes |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Interest rate |  |  |  |  |  |  |  |  | 8.00% |
Debt instrument, principal face amount |  |  |  |  |  |  |  |  | $ 9,400,000 |
Debt instrument, conversion price |  |  |  |  |  |  | $ 1,225 |  |  |
Debt instrument maturity start date |  |  |  |  | Dec. 31, 2018 |  | Dec. 31, 2018 |  |  |
Debt instrument maturity end date |  |  |  |  | Mar. 31, 2021 |  | Mar. 31, 2021 |  |  |
August 2018 Convertible Note [Member] |  |  |  |  |  |  |  |  |  |
Debt Instrument [Line Items] |  |  |  |  |  |  |  |  |  |
Notes payable maturity amount | $ 2,500 |  |  |  |  |  |  |  |  |

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