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  <xsd:element id="dcth_IncomeTaxReconciliationLossOnExtinguishmentOfDebt" name="IncomeTaxReconciliationLossOnExtinguishmentOfDebt" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_IncomeTaxRateReconciliationFederalOperatingLossCarryforwards" name="IncomeTaxRateReconciliationFederalOperatingLossCarryforwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_IncomeTaxRateReconciliationStateOperatingLossCarryforwards" name="IncomeTaxRateReconciliationStateOperatingLossCarryforwards" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_IncomeTaxReconciliationFederalTaxCredits" name="IncomeTaxReconciliationFederalTaxCredits" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToCostsAndExpenses" name="ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToCostsAndExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_IncomeTaxReconciliationDerivativeCharge" name="IncomeTaxReconciliationDerivativeCharge" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_DeferredIncomeTaxLiabilitiesBeneficialConversionFeature" name="DeferredIncomeTaxLiabilitiesBeneficialConversionFeature" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_OperatingLossCarryforwardsAnnualLimitations" name="OperatingLossCarryforwardsAnnualLimitations" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_OperatingLossCarryforwardsNetExpectedToExpireUnutilizedAndUnavailableToOffsetFutureFederalTaxableIncome" name="OperatingLossCarryforwardsNetExpectedToExpireUnutilizedAndUnavailableToOffsetFutureFederalTaxableIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_OperatingLossCarryforwardsAvailableForOffsettingAgainstFutureTaxableIncome" name="OperatingLossCarryforwardsAvailableForOffsettingAgainstFutureTaxableIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_OperatingLossCarryforwardsNotSubjectToExpiration" name="OperatingLossCarryforwardsNotSubjectToExpiration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_OperatingLossCarryForwardsExpirationYear" name="OperatingLossCarryForwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_TaxCreditCarryForwardExpirationYear" name="TaxCreditCarryForwardExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_TaxCreditCarryforwardsExpectedToExpireUnutilized" name="TaxCreditCarryforwardsExpectedToExpireUnutilized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_ExpireBetween2019And2037Member" name="ExpireBetween2019And2037Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_NewYorkCityMember" name="NewYorkCityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_DomesticAndStateTaxAuthorityMember" name="DomesticAndStateTaxAuthorityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_ValuationAllowanceDeferredTaxAssetPercentage" name="ValuationAllowanceDeferredTaxAssetPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToAdditionalPaidInCapital" name="ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToAdditionalPaidInCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToRetainedEarnings" name="ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToRetainedEarnings" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToOtherComprehensiveIncome" name="ValuationAllowanceDeferredTaxAssetChangeInAmountChargedToOtherComprehensiveIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetsProvisionalIncomeTaxExpenseBenefit" name="TaxCutsAndJobsActOf2017IncompleteAccountingChangeInTaxRateDeferredTaxAssetsProvisionalIncomeTaxExpenseBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_OpenTaxPeriod" name="OpenTaxPeriod" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_CommonStockSubscriptionPricePerShare" name="CommonStockSubscriptionPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_ProceedsFromExchangeOfPreferredStock" name="ProceedsFromExchangeOfPreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_ClassOfWarrantOrRightNumberOfWarrantsAvailableForCancellation" name="ClassOfWarrantOrRightNumberOfWarrantsAvailableForCancellation" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_GainsLossesOnExtinguishmentOfDebtExcludingWarrants" name="GainsLossesOnExtinguishmentOfDebtExcludingWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_StockIssuedDuringPeriodShares" name="StockIssuedDuringPeriodShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_StockIssuedDuringPeriodSharesExerciseOfPreFundedWarrants" name="StockIssuedDuringPeriodSharesExerciseOfPreFundedWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_StockIssuedDuringPeriodValueExerciseOfPreFundedWarrants" name="StockIssuedDuringPeriodValueExerciseOfPreFundedWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_StockIssuedDuringPeriodSharesExchangeOfWarrantsForCommonStock" name="StockIssuedDuringPeriodSharesExchangeOfWarrantsForCommonStock" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_StockIssuedDuringPeriodValueExchangeOfWarrantsForCommonStock" name="StockIssuedDuringPeriodValueExchangeOfWarrantsForCommonStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_AdjustmentsToAdditionalPaidInCapitalPreFundedWarrantIssued" name="AdjustmentsToAdditionalPaidInCapitalPreFundedWarrantIssued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_StockIssuedDuringPeriodValueCashlessExerciseOfWarrants" name="StockIssuedDuringPeriodValueCashlessExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_AdjustmentsToAdditionalPaidInCapitalFairValueOfWarrantsIssuedWithConvertibleNotes" name="AdjustmentsToAdditionalPaidInCapitalFairValueOfWarrantsIssuedWithConvertibleNotes" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_AdjustmentsToAdditionalPaidInCapitalFairValueOfWarrantsReclassifiedFromLiabilityToEquity" name="AdjustmentsToAdditionalPaidInCapitalFairValueOfWarrantsReclassifiedFromLiabilityToEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_SeriesEOnePreferredStockMember" name="SeriesEOnePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeriesDWarrantsMember" name="SeriesDWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_StockIssuedDuringPeriodSharesCashlessExerciseOfWarrants" name="StockIssuedDuringPeriodSharesCashlessExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_StockOptionCompensationIncomeExpense" name="StockOptionCompensationIncomeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_RestrictedStockCompensationIncomeExpense" name="RestrictedStockCompensationIncomeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_AmortizationOfRightOfUseAssets" name="AmortizationOfRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_InterestIncomeEarnedOnMoneyMarketAndOperatingAccounts" name="InterestIncomeEarnedOnMoneyMarketAndOperatingAccounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_EquitizationOfExpenses" name="EquitizationOfExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_LossOnIssuanceOfFinancialInstruments" name="LossOnIssuanceOfFinancialInstruments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_PaymentsOnOperatingLeases" name="PaymentsOnOperatingLeases" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_ProceedsFromSaleOfPreferredStockAndWarrants" name="ProceedsFromSaleOfPreferredStockAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_ProceedsFromSaleOfCommonStockAndWarrants" name="ProceedsFromSaleOfCommonStockAndWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_NonCashActivitiesFairValueOfWarrantsIssued" name="NonCashActivitiesFairValueOfWarrantsIssued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_SeriesEPreferredStockAndWarrantsMember" name="SeriesEPreferredStockAndWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_RestrictedCashDisclosureTextBlock" name="RestrictedCashDisclosureTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_PrepaidExpensesAndOtherCurrentAssetsTextBlock" name="PrepaidExpensesAndOtherCurrentAssetsTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_LesseeOperatingAndFinanceLeasesTextBlock" name="LesseeOperatingAndFinanceLeasesTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_LiquidityAndOperatingMattersPolicyTextBlock" name="LiquidityAndOperatingMattersPolicyTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ScheduleOfOperatingAndFinancingLeasesTableTextBlock" name="ScheduleOfOperatingAndFinancingLeasesTableTextBlock" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_LettersOfCreditRestrictedCash" name="LettersOfCreditRestrictedCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_SecurityForCreditCardsRestrictedCash" name="SecurityForCreditCardsRestrictedCash" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_PrepaidClinicalTrialExpensesCurrent" name="PrepaidClinicalTrialExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_IncomeTaxAndValueAddedTaxReceivableCurrent" name="IncomeTaxAndValueAddedTaxReceivableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_MaximumPercentageOfPrepaidExpensesAndOtherCurrentAssets" name="MaximumPercentageOfPrepaidExpensesAndOtherCurrentAssets" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_AccruedClinicalTrialExpensesCurrent" name="AccruedClinicalTrialExpensesCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_MaximumPercentageOfCurrentLiabilitiesAccrued" name="MaximumPercentageOfCurrentLiabilitiesAccrued" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_FinancingLeaseCost" name="FinancingLeaseCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_FinanceLeasePrincipalPaymentOnLiability" name="FinanceLeasePrincipalPaymentOnLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_OperatingLeaseAndFinancingLeaseWeightedAverageRemainingLeaseTerm" name="OperatingLeaseAndFinancingLeaseWeightedAverageRemainingLeaseTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_OtherLeaseInformationAbstract" name="OtherLeaseInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" name="EquityMethodInvestmentsAndCostMethodInvestmentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_PreFundedSeriesDWarrantMember" name="PreFundedSeriesDWarrantMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeniorSecuredPromissoryNotesMember" name="SeniorSecuredPromissoryNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeniorSecuredNotesMember" name="SeniorSecuredNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeniorSecuredConvertibleNoteMember" name="SeniorSecuredConvertibleNoteMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_EightPointZeroPercentageTwoThousandAndEighteenNotesMember" name="EightPointZeroPercentageTwoThousandAndEighteenNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_ShortTermNotesPayableMember" name="ShortTermNotesPayableMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_DebtInstrumentMaturityPeriod" name="DebtInstrumentMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ExchangeOfPreferredStockStatedValue" name="ExchangeOfPreferredStockStatedValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_IssuanceOfSeniorSecuredPromissoryNoteInExchangeOfPreferredStock" name="IssuanceOfSeniorSecuredPromissoryNoteInExchangeOfPreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_DebtInstrumentInterestRateOnNotesInEventOfDefaultPercentage" name="DebtInstrumentInterestRateOnNotesInEventOfDefaultPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_DebtInstrumentDebtDefaultPercentage" name="DebtInstrumentDebtDefaultPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_LongTermConvertibleNotesPayableMember" name="LongTermConvertibleNotesPayableMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_EightPointZeroPercentageJulyTwoThousandAndNineteenNotesMember" name="EightPointZeroPercentageJulyTwoThousandAndNineteenNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_DecemberFourTwoThousandEighteenMaturityDateMember" name="DecemberFourTwoThousandEighteenMaturityDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_MarchOneTwoThousandNineteenMaturityDateMember" name="MarchOneTwoThousandNineteenMaturityDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_MarchTwentyOneTwoThousandNineteenMaturityDateMember" name="MarchTwentyOneTwoThousandNineteenMaturityDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_DecemberFourTwoThousandNineteenMaturityDateMember" name="DecemberFourTwoThousandNineteenMaturityDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_MarchOneTwoThousandTwentyMaturityDateMember" name="MarchOneTwoThousandTwentyMaturityDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_MarchTwentyOneTwoThousandTwentyMaturityDateMember" name="MarchTwentyOneTwoThousandTwentyMaturityDateMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_StockholdersEquityNoteLineItems" name="StockholdersEquityNoteLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_StockholdersEquityNoteTable" name="StockholdersEquityNoteTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeriesEConvertiblePreferredStockMember" name="SeriesEConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_JulyTwoThousandNineteenPrivatePlacementMember" name="JulyTwoThousandNineteenPrivatePlacementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SecuritiesPurchaseAgreementMember" name="SecuritiesPurchaseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeriesE1ConvertiblePreferredStockMember" name="SeriesE1ConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_AugustTwoThousandNineteenPrivatePlacementMember" name="AugustTwoThousandNineteenPrivatePlacementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeriesEPreferredStockAndRelatedWarrantsMember" name="SeriesEPreferredStockAndRelatedWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_TwoThousandAndNineteenWarrantsMember" name="TwoThousandAndNineteenWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_WarrantExercisibleTerm" name="WarrantExercisibleTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_DebtAndWarrantsExchangedForPreferredStock" name="DebtAndWarrantsExchangedForPreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_NumberOfSharesIssuedUponExchangeOfAccountsPayable" name="NumberOfSharesIssuedUponExchangeOfAccountsPayable" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_NumberOfSharesIssuedUponExchangeOfInvestorWaiverRights" name="NumberOfSharesIssuedUponExchangeOfInvestorWaiverRights" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ValueOfAccountsPayableExchanged" name="ValueOfAccountsPayableExchanged" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_ExchangeAgreementMember" name="ExchangeAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_TwoThousandAndNineteenEquityIncentivePlanMember" name="TwoThousandAndNineteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_ShareBasedCompensationIncomeExpense" name="ShareBasedCompensationIncomeExpense" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="dcth_ClassOfWarrantOrRightIssued" name="ClassOfWarrantOrRightIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ClassOfWarrantOrRightExercisesInPeriod" name="ClassOfWarrantOrRightExercisesInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_WarrantsOutstandingRollForward" name="WarrantsOutstandingRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_ClassOfWarrantOrRightExercisePricePerShareRollForward" name="ClassOfWarrantOrRightExercisePricePerShareRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_ClassOfWarrantOrRightWeightedAverageExercisePrice" name="ClassOfWarrantOrRightWeightedAverageExercisePrice" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="dcth_ClassOfWarrantOrRightWeightedAverageExercisePriceIssued" name="ClassOfWarrantOrRightWeightedAverageExercisePriceIssued" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ClassOfWarrantOrRightWeightedAverageExercisePriceExercisesInPeriod" name="ClassOfWarrantOrRightWeightedAverageExercisePriceExercisesInPeriod" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ClassOfWarrantOrRightWeightedAverageExercisePriceExchanged" name="ClassOfWarrantOrRightWeightedAverageExercisePriceExchanged" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_ClassOfWarrantOrRightWeightedAverageExercisePriceRollForward" name="ClassOfWarrantOrRightWeightedAverageExercisePriceRollForward" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm" name="ClassOfWarrantOrRightWeightedAverageRemainingContractualTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="dcth_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisReclassifiedFromLiabilityToEquity" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisReclassifiedFromLiabilityToEquity" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="dcth_FebruaryTwoThousandEighteenWarrantsMember" name="FebruaryTwoThousandEighteenWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_CommonStockWarrantsEquityMember" name="CommonStockWarrantsEquityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_CommonStockWarrantsLiabilityMember" name="CommonStockWarrantsLiabilityMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_AssumedConversionOfSeriesEAndE1PreferredStockMember" name="AssumedConversionOfSeriesEAndE1PreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_AssumedConversionOfConvertibleNotesMember" name="AssumedConversionOfConvertibleNotesMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="dcth_SeriesEAndEOnePreferredStockMember" name="SeriesEAndEOnePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
