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Stockholders' Equity - Preferred Stock Issuances - Additional Information (Details) - USD ($)
 1 Months Ended 12 Months Ended
Nov. 07, 2019
Jul. 11, 2019
Mar. 29, 2019
Sep. 30, 2018
Feb. 28, 2018
Dec. 31, 2019
Dec. 31, 2018
Aug. 19, 2019
Nov. 05, 2018
Stockholders Equity Note [Line Items]                  
Preferred stock, par value (in dollars per share)           $ 0.01 $ 0.01    
Sale of common stock, net of expenses (in shares)       6,669 606        
Fair value of warrants issued           $ 20,844,000 $ 28,539,000    
Preferred stock, aggregate stated value           0 $ 0    
Common Stock [Member]                  
Stockholders Equity Note [Line Items]                  
Conversion of stock, shares issued 813,473                
Sale of common stock, net of expenses (in shares)             7,624    
2019 Warrants [Member]                  
Stockholders Equity Note [Line Items]                  
Number of shares called upon exercise of warrant 824,587                
Fair value of warrants issued           20,800,000      
Series E Convertible Preferred Stock [Member] | July 2019 Private Placement [Member] | Securities Purchase Agreement [Member]                  
Stockholders Equity Note [Line Items]                  
Number of shares issued   20,000              
Preferred stock, par value (in dollars per share)   $ 0.01              
Shares issued, price per share   $ 1,000              
Series E Preferred Stock and Related Warrants [Member]                  
Stockholders Equity Note [Line Items]                  
Debt and warrants exchanged for preferred stock           $ 11,800,000      
Number of preferred stock and warrants issued upon conversion           11,500      
Value of accounts payable exchanged           $ 100,000      
Number of shares issued upon exchange of accounts payable           149      
Number of shares issued upon exchange of investor waiver rights           923      
Series E Preferred Stock and Related Warrants [Member] | July 2019 Private Placement [Member]                  
Stockholders Equity Note [Line Items]                  
Debt and warrants exchanged for preferred stock   $ 11,800,000              
Number of preferred stock and warrants issued upon conversion   11,500              
Value of accounts payable exchanged   $ 100,000              
Number of shares issued upon exchange of accounts payable   149              
Number of shares issued upon exchange of investor waiver rights   923              
Series E-1 Convertible Preferred Stock [Member] | August 2019 Private Placement [Member] | Securities Purchase Agreement [Member]                  
Stockholders Equity Note [Line Items]                  
Number of shares issued               9,510  
Preferred stock, par value (in dollars per share)               $ 0.01  
Shares issued, price per share               $ 1,000  
Preferred Stock [Member]                  
Stockholders Equity Note [Line Items]                  
Conversion price $ 23.04         $ 42.00      
Warrant exercise price 23.04         $ 42.00      
Warrant exercisable term           5 years      
Net proceeds from issuance of preferred stock           $ 26,600,000      
Beneficial conversion feature           $ 18,300,000      
Preferred Stock and 2019 Warrants [Member]                  
Stockholders Equity Note [Line Items]                  
Conversion of stock, description           The Conversion Price of the Preferred Stock and the Exercise Price of the 2019 Warrants were initially subject to adjustment in each of the following circumstances: (i) on the third trading day following the date that the Company effects a reverse stock split, or the Reverse Split Reset Date, (ii) the date that the initial registration statement covering the shares of common stock issuable upon the conversion of the Preferred Stock and the exercise of the 2019 Warrants is declared effective by the SEC, or the Registration Reset Date, and (iii) in the event that all of the shares of common stock which we were required to register with the SEC were not then registered on an effective registration statement, the date that all of the shares underlying the respective Preferred Stock and 2019 Warrants may be sold pursuant to Rule 144, or the Rule 144 Reset Date, each of such reset dates, a Reset Date and, collectively, the Reset Dates. On each Reset Date, the Conversion Price and the Exercise Price were to be reduced, and only reduced, to equal the lesser of (x) the then effective Conversion Price or Exercise Price, as applicable, and (y) 90% of the average of the five daily volume weighted average prices of the common stock immediately prior to each Reset Date, or the Reset Formula.      
Private Placements and Debt Exchange [Member]                  
Stockholders Equity Note [Line Items]                  
Conversion price and exercise price per share $ 16.10                
Private Placements and Debt Exchange [Member] | Common Stock [Member]                  
Stockholders Equity Note [Line Items]                  
Sale of common stock, net of expenses (in shares) 3,429,680                
Second Registration Statement [Member] | Common Stock [Member]                  
Stockholders Equity Note [Line Items]                  
Sale of common stock, net of expenses (in shares) 1,564,085                
Series D Preferred Shares [Member]                  
Stockholders Equity Note [Line Items]                  
Preferred stock, par value (in dollars per share)                 $ 0.01
Preferred stock, aggregate stated value     $ 1,160,000,000            
Proceeds from exchange of senior secured promissory note     $ 400,000