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Consolidated Statement of Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Series D Preferred Stock [Member] | Series E Preferred Stock [Member] | Series E1 Preferred Stock [Member] | Common Stock [Member] | Common Stock [Member] Series D Warrants | Preferred Stock [Member] | Preferred Stock [Member] Series D Preferred Stock [Member] | Preferred Stock [Member] Series E Preferred Stock [Member] | Preferred Stock [Member] Series E1 Preferred Stock [Member] | Additional Paid in Capital [Member] | Additional Paid in Capital [Member] Series D Preferred Stock [Member] | Additional Paid in Capital [Member] Series E Preferred Stock [Member] | Additional Paid in Capital [Member] Series E1 Preferred Stock [Member] | Accumulated Deficit [Member] | Accumulated Deficit [Member] Series E Preferred Stock [Member] | Accumulated Deficit [Member] Series E1 Preferred Stock [Member] | Accumulated Other Comprehensive Income (Loss) [Member]
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2018 | $ (14,939) |  |  |  |  |  |  |  |  |  | $ 329,065 |  |  |  | $ (344,054) |  |  | $ 50
Balance (in shares) at Dec. 31, 2018 |  |  |  |  | 14,715 |  | 101 |  |  |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Compensation expense for issuance of stock options | 273 |  |  |  |  |  |  |  |  |  | 273 |  |  |  |  |  |  |
Compensation expense for issuance of restricted stock | $ 4 |  |  |  |  |  |  |  |  |  | 4 |  |  |  |  |  |  |
Compensation expense for issuance of restricted stock (in shares) | 20 |  |  |  | 20 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Preferred Stock |  | $ 150 | $ 29,536 | $ 9,510 |  |  |  |  |  |  |  | $ 150 | $ 42,876 | $ 14,408 |  | $ (13,340) | $ (4,898) |
Issuance of Preferred Stock (in shares) |  |  |  |  |  |  |  | 15 | 32,572 | 9,510 |  |  |  |  |  |  |  |
Retirement of Series D Preferred Stock |  | $ (1,160) |  |  |  |  |  |  |  |  |  | $ (1,160) |  |  |  |  |  |
Retirement of Series D Preferred Stock (in Shares) |  |  |  |  |  |  |  | (116) |  |  |  |  |  |  |  |  |  |
Exercise of pre-funded warrants (in shares) | 11,285 |  |  |  |  | 11,285 |  |  |  |  |  |  |  |  |  |  |  |
Exchange of warrants | $ 13 |  |  |  |  |  |  |  |  |  | 13 |  |  |  |  |  |  |
Exchange of warrants (in shares) |  |  |  |  | 92 |  |  |  |  |  |  |  |  |  |  |  |  |
Fair value of warrants issued | (20,844) |  |  |  |  |  |  |  |  |  | (20,844) |  |  |  |  |  |  |
Conversion of preferred stock into common stock | 1 |  |  |  |  |  |  |  |  |  | 1 |  |  |  |  |  |  |
Conversion of Preferred stock into common stock (in shares) |  |  |  |  | 13,455 |  | (565) |  |  |  |  |  |  |  |  |  |  |
Fractional rounding related to reverse stock split |  |  |  |  | $ 1 |  |  |  |  |  | (1) |  |  |  |  |  |  |
Fractional rounding related to reverse stock split (in shares) |  |  |  |  | 27,524 |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (8,879) |  |  |  |  |  |  |  |  |  |  |  |  |  | (8,879) |  |  |
Comprehensive loss | (22) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (22)
Balance at Dec. 31, 2019 | (6,357) |  |  |  | $ 1 |  |  |  |  |  | 364,785 |  |  |  | (371,171) |  |  | 28
Balance (in shares) at Dec. 31, 2019 |  |  |  |  | 67,091 |  | 41,517 |  |  |  |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Compensation expense for issuance of stock options | $ 3,505 |  |  |  |  |  |  |  |  |  | 3,505 |  |  |  |  |  |  |
Compensation expense for issuance of restricted stock (in shares) | 72,976 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares settled for services | $ 406 |  |  |  | $ 1 |  |  |  |  |  | 405 |  |  |  |  |  |  |
Shares settled for services (in shares) |  |  |  |  | 50,013 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares settled for accrued compensation | $ 230 |  |  |  |  |  |  |  |  |  | 230 |  |  |  |  |  |  |
Shares settled for accrued compensation (in shares) |  |  |  |  | 22,963 |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of pre-funded warrants (in shares) | 6,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock into common stock | $ (1) |  |  |  | $ 20 |  |  |  |  |  | (21) |  |  |  |  |  |  |
Conversion of Preferred stock into common stock (in shares) |  |  |  |  | 2,084,507 |  | (20,887) |  |  |  |  |  |  |  |  |  |  |
Registration costs of Series E and Series E-1 Preferred Stock and related warrants | (106) |  |  |  |  |  |  |  |  |  | (106) |  |  |  |  |  |  |
Fair value of warrants reclassified from liability to equity | 6,200 |  |  |  |  |  |  |  |  |  | 6,200 |  |  |  |  |  |  |
Exercise of warrants into common stock | 1,858 |  |  |  | $ 2 |  |  |  |  |  | 1,856 |  |  |  |  |  |  |
Exercise of warrants into common stock (in shares) |  |  |  |  | 191,803 |  |  |  |  |  |  |  |  |  |  |  |  |
Public Offering - issuance of common stock and warrants | 19,378 |  |  |  | $ 18 |  |  |  |  |  | 19,360 |  |  |  |  |  |  |
Public Offering - issuance of common stock and warrants (in shares) |  |  |  |  | 1,823,000 |  |  |  |  |  |  |  |  |  |  |  |  |
ATM Offering | 866 |  |  |  | $ 1 |  |  |  |  |  | 865 |  |  |  |  |  |  |
ATM Offering, Shares |  |  |  |  | 77,644 |  |  |  |  |  |  |  |  |  |  |  |  |
Confidentially Marketed Public Offering - issuance of common stock | 20,387 |  |  |  | $ 17 |  |  |  |  |  | 20,370 |  |  |  |  |  |  |
Confidentially Marketed Public Offering - issuance of common stock (in shares) |  |  |  |  | 1,679,031 |  |  |  |  |  |  |  |  |  |  |  |  |
Fractional rounding related to reverse stock split (in shares) |  |  |  |  | 49 |  | 1 |  |  |  |  |  |  |  |  |  |  |
Net loss | (24,156) |  |  |  |  |  |  |  |  |  |  |  |  |  | (24,156) |  |  |
Comprehensive loss | (132) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (132)
Balance at Dec. 31, 2020 | $ 22,078 |  |  |  | $ 60 |  |  |  |  |  | $ 417,449 |  |  |  | $ (395,327) |  |  | $ (104)
Balance (in shares) at Dec. 31, 2020 |  |  |  |  | 5,996,101 |  | 20,631 |  |  |  |  |  |  |  |  |  |  |

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