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Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Unaudited) - USD ($) $ in Thousands | Total | Preferred Stock [Member] | Common Stock [Member] | Additional Paid In Capital [Member] | Accumulated Deficit [Member] | Accumulated Other Comprehensive Income [Member]
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2019 | $ (6,357) |  | $ 1 | $ 364,785 | $ (371,171) | $ 28
Balance (in shares) at Dec. 31, 2019 |  | 41,517 | 67,091 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Compensation expense for issuance of stock options | 25 |  |  | 25 |  |
Shares settled for services | 30 |  |  | 30 |  |
Shares settled for services (in shares) |  |  | 2,717 |  |  |
Conversion of Preferred stock into common stock (in shares) |  | (70) | 2,915 |  |  |
Fractional rounding related to Reverse stock split (in shares) |  |  | 50 |  |  |
Registration costs | (106) |  |  | (106) |  |
Fair value of warrants reclassified from liability to equity | 6,199 |  |  | 6,199 |  |
Net loss | (7,861) |  |  |  | (7,861) |
Total comprehensive loss | 65 |  |  |  |  | 65
Balance at Mar. 31, 2020 | (8,005) |  | $ 1 | 370,933 | (379,032) | 93
Balance (in shares) at Mar. 31, 2020 |  | 41,447 | 72,773 |  |  |
Balance at Dec. 31, 2019 | (6,357) |  | $ 1 | 364,785 | (371,171) | 28
Balance (in shares) at Dec. 31, 2019 |  | 41,517 | 67,091 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (17,127) |  |  |  |  |
Balance at Sep. 30, 2020 | 3,276 |  | $ 40 | 391,545 | (388,298) | (11)
Balance (in shares) at Sep. 30, 2020 |  | 21,473 | 4,035,558 |  |  |
Balance at Mar. 31, 2020 | (8,005) |  | $ 1 | 370,933 | (379,032) | 93
Balance (in shares) at Mar. 31, 2020 |  | 41,447 | 72,773 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Shares settled for services | 606 |  | $ 1 | 605 |  |
Shares settled for services (in shares) |  |  | 70,259 |  |  |
Conversion of Preferred stock into common stock | (1) |  | $ 15 | (16) |  |
Conversion of Preferred stock into common stock (in shares) |  | (15,497) | 1,549,609 |  |  |
Conversion of Pre-funded Series F Warrants |  |  | 6,000 |  |  |
Public Offering - issuance of common stock and warrants | 19,378 |  | $ 18 | 19,360 |  |
Public Offering - issuance of common stock and warrants (in shares) |  |  | 1,823,000 |  |  |
Net loss | (4,275) |  |  |  | (4,275) |
Total comprehensive loss | (1) |  |  |  |  | (1)
Balance at Jun. 30, 2020 | 7,702 |  | $ 35 | 390,882 | (383,307) | 92
Balance (in shares) at Jun. 30, 2020 |  | 25,950 | 3,521,641 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Conversion of Preferred stock into common stock |  |  | $ 4 | (4) |  |
Conversion of Preferred stock into common stock (in shares) |  | (4,477) | 447,700 |  |  |
Exercise of Series F Warrants | 602 |  | $ 1 | 601 |  |
Exercise of Series F Warrants (shares) |  |  | 60,117 |  |  |
ATM Offerings | 66 |  |  | 66 |  |
ATM offering (shares) |  |  | 6,100 |  |  |
Net loss | (4,991) |  |  |  | (4,991) |
Total comprehensive loss | (103) |  |  |  |  | (103)
Balance at Sep. 30, 2020 | 3,276 |  | $ 40 | 391,545 | (388,298) | (11)
Balance (in shares) at Sep. 30, 2020 |  | 21,473 | 4,035,558 |  |  |
Balance at Dec. 31, 2020 | 22,078 |  | $ 60 | 417,449 | (395,327) | (104)
Balance (in shares) at Dec. 31, 2020 |  | 20,631 | 5,996,101 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Compensation expense for issuance of stock options | 2,148 |  |  | 2,148 |  |
Shares settled for services | 57 |  |  | $ 57 |  |
Shares settled for services (in shares) |  |  | 2,636 |  |  |
Conversion of Preferred stock into common stock (in shares) |  | (150) | 15,000 |  |  |
Exercise of warrants into common stock | 2,376 |  | $ 3 |  |  |
Exchange of warrants (in shares) |  |  | 237,520 | 2,373 |  |
Net loss | (6,747) |  |  |  | (6,747) |
Total comprehensive loss | 94 |  |  |  |  | 94
Balance at Mar. 31, 2021 | 20,006 |  | $ 63 | $ 422,027 | (402,074) | (10)
Balance (in shares) at Mar. 31, 2021 |  | 20,481 | 6,251,257 |  |  |
Balance at Dec. 31, 2020 | 22,078 |  | $ 60 | 417,449 | (395,327) | (104)
Balance (in shares) at Dec. 31, 2020 |  | 20,631 | 5,996,101 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Net loss | (20,302) |  |  |  |  |
Balance at Sep. 30, 2021 | 11,726 |  | $ 74 | 427,301 | (415,629) | (20)
Balance (in shares) at Sep. 30, 2021 |  | 11,707 | 7,356,289 |  |  |
Balance at Mar. 31, 2021 | 20,006 |  | $ 63 | 422,027 | (402,074) | (10)
Balance (in shares) at Mar. 31, 2021 |  | 20,481 | 6,251,257 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Compensation expense for issuance of stock options | 1,626 |  |  | 1,626 |  |
Conversion of Preferred stock into common stock | 1 |  | $ 9 | (8) |  |
Conversion of Preferred stock into common stock (in shares) |  | (8,774) | 877,379 |  |  |
Exercise of warrants into common stock | 17 |  | $ 2 | 15 |  |
Exchange of warrants (in shares) |  |  | 221,141 |  |  |
Net loss | (6,430) |  |  |  | (6,430) |
Total comprehensive loss | (61) |  |  |  |  | (61)
Balance at Jun. 30, 2021 | 15,159 |  | $ 74 | 423,660 | (408,504) | (71)
Balance (in shares) at Jun. 30, 2021 |  | 11,707 | 7,349,777 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Compensation expense for issuance of stock options | 2,449 |  |  | 2,449 |  |
Proceeds allocated to warrant | 1,171 |  |  | 1,171 |  |
Cash issuance costs of warrant | (44) |  |  | (44) |  |
Exercise of warrants into common stock | 65 |  |  | 65 |  |
Exchange of warrants (in shares) |  |  | 6,512,000 |  |  |
Net loss | (7,125) |  |  |  | (7,125) |
Total comprehensive loss | 51 |  |  |  |  | 51
Balance at Sep. 30, 2021 | $ 11,726 |  | $ 74 | $ 427,301 | $ (415,629) | $ (20)
Balance (in shares) at Sep. 30, 2021 |  | 11,707 | 7,356,289 |  |  |

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