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Condensed Consolidated Statements of Stockholders' Equity (Deficit) (Unaudited) - USD ($)
$ in Thousands
Total
Preferred Stock [Member]
Common Stock [Member]
Additional Paid In Capital [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income [Member]
Balance at Dec. 31, 2019 $ (6,357)   $ 1 $ 364,785 $ (371,171) $ 28
Balance (in shares) at Dec. 31, 2019   41,517 67,091      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Compensation expense for issuance of stock options 25     25    
Shares settled for services 30     30    
Shares settled for services (in shares)     2,717      
Conversion of Preferred stock into common stock (in shares)   (70) 2,915      
Fractional rounding related to Reverse stock split (in shares)     50      
Registration costs (106)     (106)    
Fair value of warrants reclassified from liability to equity 6,199     6,199    
Net loss (7,861)       (7,861)  
Total comprehensive loss 65         65
Balance at Mar. 31, 2020 (8,005)   $ 1 370,933 (379,032) 93
Balance (in shares) at Mar. 31, 2020   41,447 72,773      
Balance at Dec. 31, 2019 (6,357)   $ 1 364,785 (371,171) 28
Balance (in shares) at Dec. 31, 2019   41,517 67,091      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (17,127)          
Balance at Sep. 30, 2020 3,276   $ 40 391,545 (388,298) (11)
Balance (in shares) at Sep. 30, 2020   21,473 4,035,558      
Balance at Mar. 31, 2020 (8,005)   $ 1 370,933 (379,032) 93
Balance (in shares) at Mar. 31, 2020   41,447 72,773      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Shares settled for services 606   $ 1 605    
Shares settled for services (in shares)     70,259      
Conversion of Preferred stock into common stock (1)   $ 15 (16)    
Conversion of Preferred stock into common stock (in shares)   (15,497) 1,549,609      
Conversion of Pre-funded Series F Warrants     6,000      
Public Offering - issuance of common stock and warrants 19,378   $ 18 19,360    
Public Offering - issuance of common stock and warrants (in shares)     1,823,000      
Net loss (4,275)       (4,275)  
Total comprehensive loss (1)         (1)
Balance at Jun. 30, 2020 7,702   $ 35 390,882 (383,307) 92
Balance (in shares) at Jun. 30, 2020   25,950 3,521,641      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Conversion of Preferred stock into common stock     $ 4 (4)    
Conversion of Preferred stock into common stock (in shares)   (4,477) 447,700      
Exercise of Series F Warrants 602   $ 1 601    
Exercise of Series F Warrants (shares)     60,117      
ATM Offerings 66     66    
ATM offering (shares)     6,100      
Net loss (4,991)       (4,991)  
Total comprehensive loss (103)         (103)
Balance at Sep. 30, 2020 3,276   $ 40 391,545 (388,298) (11)
Balance (in shares) at Sep. 30, 2020   21,473 4,035,558      
Balance at Dec. 31, 2020 22,078   $ 60 417,449 (395,327) (104)
Balance (in shares) at Dec. 31, 2020   20,631 5,996,101      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Compensation expense for issuance of stock options 2,148     2,148    
Shares settled for services 57     $ 57    
Shares settled for services (in shares)     2,636      
Conversion of Preferred stock into common stock (in shares)   (150) 15,000      
Exercise of warrants into common stock 2,376   $ 3      
Exchange of warrants (in shares)     237,520 2,373    
Net loss (6,747)       (6,747)  
Total comprehensive loss 94         94
Balance at Mar. 31, 2021 20,006   $ 63 $ 422,027 (402,074) (10)
Balance (in shares) at Mar. 31, 2021   20,481 6,251,257      
Balance at Dec. 31, 2020 22,078   $ 60 417,449 (395,327) (104)
Balance (in shares) at Dec. 31, 2020   20,631 5,996,101      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss (20,302)          
Balance at Sep. 30, 2021 11,726   $ 74 427,301 (415,629) (20)
Balance (in shares) at Sep. 30, 2021   11,707 7,356,289      
Balance at Mar. 31, 2021 20,006   $ 63 422,027 (402,074) (10)
Balance (in shares) at Mar. 31, 2021   20,481 6,251,257      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Compensation expense for issuance of stock options 1,626     1,626    
Conversion of Preferred stock into common stock 1   $ 9 (8)    
Conversion of Preferred stock into common stock (in shares)   (8,774) 877,379      
Exercise of warrants into common stock 17   $ 2 15    
Exchange of warrants (in shares)     221,141      
Net loss (6,430)       (6,430)  
Total comprehensive loss (61)         (61)
Balance at Jun. 30, 2021 15,159   $ 74 423,660 (408,504) (71)
Balance (in shares) at Jun. 30, 2021   11,707 7,349,777      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Compensation expense for issuance of stock options 2,449     2,449    
Proceeds allocated to warrant 1,171     1,171    
Cash issuance costs of warrant (44)     (44)    
Exercise of warrants into common stock 65     65    
Exchange of warrants (in shares)     6,512,000      
Net loss (7,125)       (7,125)  
Total comprehensive loss 51         51
Balance at Sep. 30, 2021 $ 11,726   $ 74 $ 427,301 $ (415,629) $ (20)
Balance (in shares) at Sep. 30, 2021   11,707 7,356,289