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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Common Stock [Member] | Preferred Stock [Member] | Additional Paid in Capital [Member] | Accumulated Deficit [Member] | Accumulated Other Comprehensive Income (Loss) [Member]
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2019 | $ (6,357) | $ 1 |  | $ 364,785 | $ (371,171) | $ 28
Balance (in shares) at Dec. 31, 2019 |  | 67,091 | 41,517 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Compensation expense for issuance of stock options | 3,505 |  |  | 3,505 |  |
Shares settled for services | 406 | $ 1 |  | 405 |  |
Shares settled for services (in shares) |  | 50,013 |  |  |  |
Conversion of preferred stock into common stock |  | $ 20 |  | (20) |  |
Conversion of Preferred stock into common stock (in shares) |  | 2,084,507 | (20,887) |  |  |
Shares settled for accrued compensation | 229 |  |  | 229 |  |
Shares settled for accrued compensation (in shares) |  | 22,963 |  |  |  |
Exchange of warrants | 1,858 | $ 2 |  | 1,856 |  |
Exchange of warrants (in shares) |  | 191,803 |  |  |  |
Common stock issued in connection with ATM Offering | 867 | $ 1 |  | 866 |  |
Common stock issued in connection with ATM Offering (Shares) |  | 77,644 |  |  |  |
Registration costs of Series E and Series E-1 Preferred Stock and related warrants | (106) |  |  | (106) |  |
Fair value of warrants reclassified from liability to equity | 6,199 |  |  | 6,199 |  |
Public Offering - issuance of common stock and warrants | 19,378 | $ 18 |  | 19,360 |  |
Public Offering - issuance of common stock and warrants (in shares) |  | 1,823,000 |  |  |  |
Confidentially Marketed Public Offering - issuance of common stock | 20,387 | $ 17 |  | 20,370 |  |
Confidentially Marketed Public Offering - issuance of common stock (in shares) |  | 1,679,031 |  |  |  |
Fractional rounding related to reverse stock split (in shares) |  | 49 | 1 |  |  |
Net loss | (24,156) |  |  |  | (24,156) |
Total comprehensive income (loss) | (132) |  |  |  |  | (132)
Balance at Dec. 31, 2020 | 22,078 | $ 60 |  | 417,449 | (395,327) | (104)
Balance (in shares) at Dec. 31, 2020 |  | 5,996,101 | 20,631 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Compensation expense for issuance of stock options | 7,832 |  |  | 7,832 |  |
Shares settled for services | 57 |  |  | 57 |  |
Shares settled for services (in shares) |  | 2,636 |  |  |  |
Conversion of preferred stock into common stock | 0 | $ 9 |  | (9) |  |
Conversion of Preferred stock into common stock (in shares) |  | 927,379 | (9,274) |  |  |
Exchange of warrants | 2,458 | $ 5 |  | 2,453 |  |
Exchange of warrants (in shares) |  | 465,173 |  |  |  |
Proceeds allocated to warrant | 1,171 |  |  | 1,171 |  |
Cash issuance costs of warrant | (44) |  |  | (44) |  |
Exercise of options into common stock | $ 4 |  |  | 4 |  |
Exercise of options into common stock (shares) | 439 | 439 |  |  |  |
Common stock issued in connection with ATM Offering | $ 3,923 | $ 5 |  | 3,918 |  |
Common stock issued in connection with ATM Offering (Shares) |  | 515,000 |  |  |  |
Net loss | (25,649) |  |  |  | (25,649) |
Total comprehensive income (loss) | 122 |  |  |  |  | 122
Balance at Dec. 31, 2021 | $ 11,952 | $ 79 |  | $ 432,831 | $ (420,976) | $ 18
Balance (in shares) at Dec. 31, 2021 |  | 7,906,728 | 11,357 |  |  |

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