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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($)
$ in Thousands
Total
Common Stock [Member]
Preferred Stock [Member]
Additional Paid in Capital [Member]
Accumulated Deficit [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Balance at Dec. 31, 2019 $ (6,357) $ 1   $ 364,785 $ (371,171) $ 28
Balance (in shares) at Dec. 31, 2019   67,091 41,517      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Compensation expense for issuance of stock options 3,505     3,505    
Shares settled for services 406 $ 1   405    
Shares settled for services (in shares)   50,013        
Conversion of preferred stock into common stock   $ 20   (20)    
Conversion of Preferred stock into common stock (in shares)   2,084,507 (20,887)      
Shares settled for accrued compensation 229     229    
Shares settled for accrued compensation (in shares)   22,963        
Exchange of warrants 1,858 $ 2   1,856    
Exchange of warrants (in shares)   191,803        
Common stock issued in connection with ATM Offering 867 $ 1   866    
Common stock issued in connection with ATM Offering (Shares)   77,644        
Registration costs of Series E and Series E-1 Preferred Stock and related warrants (106)     (106)    
Fair value of warrants reclassified from liability to equity 6,199     6,199    
Public Offering - issuance of common stock and warrants 19,378 $ 18   19,360    
Public Offering - issuance of common stock and warrants (in shares)   1,823,000        
Confidentially Marketed Public Offering - issuance of common stock 20,387 $ 17   20,370    
Confidentially Marketed Public Offering - issuance of common stock (in shares)   1,679,031        
Fractional rounding related to reverse stock split (in shares)   49 1      
Net loss (24,156)       (24,156)  
Total comprehensive income (loss) (132)         (132)
Balance at Dec. 31, 2020 22,078 $ 60   417,449 (395,327) (104)
Balance (in shares) at Dec. 31, 2020   5,996,101 20,631      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Compensation expense for issuance of stock options 7,832     7,832    
Shares settled for services 57     57    
Shares settled for services (in shares)   2,636        
Conversion of preferred stock into common stock 0 $ 9   (9)    
Conversion of Preferred stock into common stock (in shares)   927,379 (9,274)      
Exchange of warrants 2,458 $ 5   2,453    
Exchange of warrants (in shares)   465,173        
Proceeds allocated to warrant 1,171     1,171    
Cash issuance costs of warrant (44)     (44)    
Exercise of options into common stock $ 4     4    
Exercise of options into common stock (shares) 439 439        
Common stock issued in connection with ATM Offering $ 3,923 $ 5   3,918    
Common stock issued in connection with ATM Offering (Shares)   515,000        
Net loss (25,649)       (25,649)  
Total comprehensive income (loss) 122         122
Balance at Dec. 31, 2021 $ 11,952 $ 79   $ 432,831 $ (420,976) $ 18
Balance (in shares) at Dec. 31, 2021   7,906,728 11,357