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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Cash flows from operating activities:    
Net loss $ (25,649) $ (24,156)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock option compensation expense 7,832 3,505
Restricted stock compensation expense   406
Depreciation expense 146 167
Amortization of right of use assets 322 25
Amortization of debt discount 323  
Warrant liability fair value adjustment   2,832
Non-cash interest income   (1)
Interest expense accrued related to convertible notes 186 160
Changes in assets and liabilities:    
Increase (decrease) in prepaid expenses and other assets 813 (910)
Increase (decrease) in accounts receivable 13 (36)
Increase in inventories (557) (201)
Decrease in accounts payable (1,136) (4,396)
Decrease in accrued expenses (2,148) 0
Decrease in lease liabilities (322)  
Decrease in deferred revenue (2,427) (263)
Net cash used in operating activities (22,604) (22,868)
Cash flows from investing activities:    
Purchase of property, plant and equipment (143) (782)
Net cash used in investing activities (143) (782)
Cash flows from financing activities:    
Principal payments of financing leases   (26)
Payments related to registration costs   (106)
Net proceeds from Public Offerings [1]   39,764
Fees paid related to preferred stock conversions   (1)
Net proceeds from ATM Offering [2],[3] 3,923 866
Net proceeds from debt financing [4] 14,437  
Proceeds from the exercise of stock options 4 0
Proceeds from the exercise of warrants 2,458 1,858
Net cash provided by financing activities 20,822 42,355
Foreign currency effects on cash 122 (132)
Net (decrease) increase in total cash (1,803) 18,573
Total Cash, Cash Equivalents and Restricted Cash:    
Beginning of period 28,756 10,183
End of period 26,953 28,756
Cash 22,802 28,575
Restricted Cash 4,151 181
Total 26,953 28,756
Supplemental Disclosure of Cash Flow Information:    
Interest expense 681 11
Supplemental Disclosure of Non-Cash Investing and Financing Activities:    
Conversions of preferred stock into common stock   21
Shares settled for services 57  
Proceeds allocated to warrant 1,171  
Reclassification of 2019 warrants from liability to equity   6,200
Right of use assets obtained in exchange for lease obligations 192 729
Financing of D&O insurance premium $ 886 781
Issuance of restricted stock for 2019 bonuses due to executive officers   $ 230
[1] Includes gross proceeds of $44,243, less total issuance costs of $4,479.
[2] For 2020, includes gross proceeds of $910, less total issuance costs of $44.
[3] For 2021, includes gross proceeds of $4,044, less total issuance costs of $121.
[4] Includes gross proceeds of $15,000 less total costs of $563.