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Loans and Convertible Notes Payable (Tables) |  | 3 Months Ended
--- | --- | ---
Aug. 06, 2021 | Mar. 31, 2022
Debt Disclosure [Abstract] |  |
Summary of Loans and Convertible Notes Payable |  |
|  | March 31, 2022 |  |  | December 31, 2021 |
|  | Gross |  |  | Discount |  |  | Net |  |  | Gross |  |  | Discount |  |  | Net |
Loan - Avenue [1] |  |  | 12,638 |  |  |  | (1,485 | ) |  |  | 11,153 |  |  |  | 12,638 |  |  |  | (1,645 | ) |  |  | 10,993 |
Loan - Avenue [1] - Less Current Portion |  |  | (2,856 | ) |  |  | 336 |  |  |  | (2,520 | ) |  |  | (714 | ) |  |  | 93 |  |  |  | (621 | )
Total - Loans Payable, Non-Current |  | $ | 9,782 |  |  | $ | (1,149 | ) |  | $ | 8,633 |  |  | $ | 11,924 |  |  | $ | (1,552 | ) |  | $ | 10,372 |
Convertible Note Payable - Rosalind |  |  | 2,000 |  |  |  | — |  |  |  | 2,000 |  |  |  | 2,000 |  |  |  | — |  |  |  | 2,000 |
Convertible Portion of Loan Payable - Avenue |  |  | 3,000 |  |  |  | (325 | ) |  |  | 2,675 |  |  |  | 3,000 |  |  |  | (361 | ) |  |  | 2,639 |
Total - Convertible Notes Payable - Non-Current |  | $ | 5,000 |  |  | $ | (325 | ) |  | $ | 4,675 |  |  | $ | 5,000 |  |  | $ | (361 | ) |  | $ | 4,639 |
[1] | The gross amount includes the 4.25% final payment of $638,000.
Summary of Remaining Maturities of Company's Loan and Convertible Note Payables |  | Remaining maturities of the Company’s loan and convertible note payables are as follows (in thousands):
|  | Loans |  |  | Convertible Notes |  |  | Total |
Year ended December 31, 2022 |  | $ | 714 |  |  | $ | — |  |  | $ | 714 |
Year ended December 31, 2023 |  |  | 8,571 |  |  |  | — |  |  |  | 8,571 |
Year ended December 31, 2024 |  |  | 3,353 |  |  |  | 5,000 |  |  |  | 8,353 |
Total |  | $ | 12,638 |  |  | $ | 5,000 |  |  | $ | 17,638 |
Summary of Avenue Warrant Valued Using the Black-Scholes Option Pricing Method | The Avenue Warrant was valued at issuance at $1.3 million using the Black-Scholes option pricing method using the following assumptions:
|  | August 6, 2021 |
Contractual term (years) |  |  | 5.07 |
Expected volatility |  |  | 187.0 | %
Risk-free interest rate |  |  | 0.77 | %
Expected dividends |  |  | 0.00 | %
| The Company values stock options using the Black-Scholes option pricing model and used the following assumptions during the reporting periods:
|  | Three months ended March 31,
|  | 2022 |  | 2021 |
Expected terms (years) |  |  | 5.46 - 6.46 |  | N/A |
Expected volatility |  |  | 174.81% - 177.09 | % | N/A |
Risk-free interest rate |  |  | 1.75% - 1.90 | % | N/A |
Expected dividends |  |  | 0.00 | % | N/A |

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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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