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Commitments and contingencies - Additional Information (Details) $ in Thousands, € in Millions	Oct. 25, 2022	Sep. 30, 2022 USD ($)	Apr. 01, 2020	Mar. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Apr. 01, 2021 USD ($)	Apr. 01, 2021 EUR (€)
Loss Contingencies [Line Items]
Percentage of enrolled patients		87.00%
Inventory		$ 1,926			$ 1,412
Medac [Member]
Loss Contingencies [Line Items]
Due from related parties						$ 1,000	€ 1
Agreement date			Dec. 10, 2018
Inventory				$ 200
Medac [Member] | Definitive Settlement Agreement [Member] | Other Noncurrent Liabilities [Member]
Loss Contingencies [Line Items]
Accrued unpaid compensation amounts		$ 1,200
Medac [Member] | Subsequent Event [Member] | Definitive Settlement Agreement [Member]
Loss Contingencies [Line Items]
Term over which the royalty is to be paid	5 years

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