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Stockholders' Equity (Tables)

12 Months Ended

Aug. 06, 2021

Dec. 31, 2022

Stockholders' Equity Note [Abstract]

Summary of Avenue Warrant Valued Using the Black-Scholes Option Pricing Method

The Avenue Warrant was valued at issuance at $1.3 million using the Black-Scholes option pricing method using the following assumptions:

		August 6, 2021
Contractual term (years)			5.07
Expected volatility			187.0	%
Risk-free interest rate			0.77	%
Expected dividends			0.00	%

The Company values stock options using the Black-Scholes option pricing model and used the following assumptions during the reporting periods:

		Years Ended December 31
		2022		2021
Expected terms (years)		0.7 - 8.4		5.1 - 6.3
Expected volatility		166.4% -180.3%		177.%  - 181.3%
Risk-free interest rate		1.2% - 4.4%		0.7% - 1.3%
Expected dividends		0.00%		0.00%

Summary of Stock Option Activity

The following is a summary of stock option activity for the year ended December 31, 2022:

		Number of Options				Weighted Average Exercise Price Per Share				Weighted Average Remaining Contractual Term (in years)				Aggregate Intrinsic Value
Outstanding at January 1, 2022			1,732,460			$	11.69
Granted			702,583				6.74
Expired			(65,690	)			10.43
Cancelled/Forfeited			(134,301	)			9.59
Outstanding at December 31, 2022			2,235,052			$	10.30				8.0			$	36
Exercisable at December 31, 2022			1,316,515			$	11.13				7.6			$	—

Summary of Stock Option Shares Outstanding and Exercisable

The following table summarizes information for stock option shares outstanding and exercisable at December 31, 2022:

						Options Exercisable
						Weighted Average
		Outstanding Number of				Remaining Option Term
Range of Exercise Prices		Options				(in years)				Number of Options
$6.24 - $53.85			2,234,553				8.0				1,316,016
$53.85+			499				6.1				499
			2,235,052				7.6				1,316,515

Summary of Recognized Share-based Compensation Cost

At December 31, 2022, there was approximately $2.8 million of aggregate unrecognized compensation expense related to employee and board stock option grants. The cost is expected to be recognized over a weighted average period of 1.6 years. For the years ended December 31, 2022 and 2021, the Company recognized compensation expense $7.9 million and $7.8 million, respectively, related to stock options granted to employees and board members, which were charged to the statement of operations as detailed below:

		Years Ended December 31,
		2022				2021
Selling, general and administrative		$	5,282			$	5,334
Research and development			2,449				2,311
Cost of goods sold			210				187
Total		$	7,941			$	7,832

Summary of Warrant Activity

The following is a summary of warrant activity for the year ended December 31, 2022:

										Weighted Average
						Weighted Average				Remaining Life
		Warrants				Exercise Price				(in years)
Outstanding at January 1, 2022			3,894,498			$	9.27
Warrants issued			1,258,793				.01
Outstanding at December 31, 2022			5,153,291			$	7.01				2.8
Exercisable at December 31, 2022			5,153,291			$	7.01				2.8

Schedule of Information Related to Stock Warrants Outstanding and Exercisable

The following table presents information related to stock warrants at December 31, 2022:

						Warrants Exercisable
Range of Exercise Prices		Outstanding Number of Warrants				Weighted Average Remaining Warrant Term (in years)				Number of Warrants
$0.01			1,542,548				4.4				1,542,548
$10.00			3,610,743				2.2				3,610,743
			5,153,291				2.8				5,153,291

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