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Unaudited Selected Quarterly Financial Data (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Quarterly Financial Information [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenue | $ 25,722 | $ 25,118 | $ 20,747 | $ 19,127 | $ 36,281 | $ 13,917 | $ 24,939 | $ 17,645 | $ 90,714 | $ 92,782 | $ 60,594
Total gross profit | 11,374 | 12,638 | 10,644 | 9,504 | 26,466 | 6,551 | 14,506 | 5,927 | 44,160 | 53,450 | 23,402
Total operating expenses | 29,248 | 29,373 | 28,714 | 28,069 | 27,528 | 3,937 | 25,864 | 25,255 | 115,404 | 82,584 | 86,256
Income (loss) from operations | (17,874) | (16,735) | (18,070) | (18,565) | (1,062) | 2,614 | (11,358) | (19,328) | (71,244) | (29,134) | (62,854)
Net income (loss) | $ (19,030) | $ (17,494) | $ (18,499) | $ (19,352) | $ (1,409) | $ 1,821 | $ (11,935) | $ (20,173) | $ (74,375) | $ (31,696) | $ (66,160)
Basic and diluted net loss per share | $ (0.21) | $ (0.19) | $ (0.21) | $ (0.23) |  |  |  |  |  |  |
Weighted average shares used in computation of basic and diluted net loss per share | 92,660 | 92,110 | 88,148 | 83,604 |  |  |  |  | 89,148 | 75,614 | 70,475
Net income (loss) per share, basic |  |  |  |  | $ (0.02) | $ 0.02 | $ (0.16) | $ (0.27) |  |  |
Net income (loss) per share, diluted |  |  |  |  | $ (0.02) | $ 0.02 | $ (0.16) | $ (0.27) |  |  |
Weighted average number of shares used in computing basic net income (loss) per share |  |  |  |  | 78,327 | 75,205 | 74,733 | 74,149 |  |  |
Weighted average number of shares used in computing diluted net income (loss) per share |  |  |  |  | 78,327 | 80,479 | 74,733 | 74,149 |  |  |
Gain on lease amendments |  |  |  |  |  |  |  |  |  | $ 23,043 |
Roche Agreement [Member] |  |  |  |  |  |  |  |  |  |  |
Quarterly Financial Information [Line Items] |  |  |  |  |  |  |  |  |  |  |
Basic and diluted net loss per share |  |  |  |  |  |  |  |  |  | $ (0.10) |
Deferred revenue, revenue recognized | $ 1,300 |  |  |  | $ 20,000 |  | $ 10,000 |  |  |  |
Lease Amendment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |
Quarterly Financial Information [Line Items] |  |  |  |  |  |  |  |  |  |  |
Gain on lease amendments |  |  |  |  |  | $ 23,000 |  |  |  |  |

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