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Consolidated Statements Of Operations And Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Revenue: |  |  |
Product revenue | $ 64,609 | $ 37,502 | $ 35,299
Service and other revenue | 13,971 | 10,896 | 8,511
Contractual revenue | 12,134 | 44,384 | 16,784
Total revenue | 90,714 | 92,782 | 60,594
Cost of Revenue: |  |  |
Cost of product revenue | 34,512 | 30,704 | 29,626
Cost of service and other revenue | 12,042 | 8,628 | 7,566
Total cost of revenue | 46,554 | 39,332 | 37,192
Gross profit | 44,160 | 53,450 | 23,402
Operating Expense: |  |  |
Research and development | 67,617 | 60,440 | 48,230
Sales, general and administrative | 47,787 | 45,187 | 38,026
Gain on lease amendments |  | (23,043) |
Total operating expense | 115,404 | 82,584 | 86,256
Operating loss | (71,244) | (29,134) | (62,854)
Interest expense | (3,234) | (2,926) | (2,828)
Other income (expense), net | 103 | 364 | (478)
Net loss | (74,375) | (31,696) | (66,160)
Other comprehensive loss: |  |  |
Unrealized gain (loss) on investments | 12 | (16) | (5)
Comprehensive loss | $ (74,363) | $ (31,712) | $ (66,165)
Net loss per share: |  |  |
Basic and diluted net loss per share | $ (0.83) | $ (0.42) | $ (0.94)
Shares used in computing basic and diluted net loss per share | 89,148 | 75,614 | 70,475

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