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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Income Taxes [Abstract]

Reconciliation Of Federal Income Tax Rate



	Years ended December 31,
	2016			2015			2014
Statutory tax rate	35.0	%		35.0	%		35.0	%
State tax rate, net of federal benefit	5.4			(3.5)			3.8
Stock-based compensation	(1.6)			(4.0)			(1.3)
R&D credit	5.0			11.0			4.0
Other	(0.9)			(0.6)			(0.0)
Change in valuation allowance	(42.9)			(37.9)			(41.5)
Effective income tax rate	0.0	%		0.0	%		0.0	%



Reconciliation Of Deferred Tax Assets And Liabilities



	December 31,
Deferred tax assets:	2016			2015
Net operating loss carryforwards	$	264,183		$	235,659
Research and development credits		32,043			28,346
Depreciation		1,170			1,403
Accruals and reserves		20,088			20,385
Total deferred tax assets		317,484			285,793
Less: Valuation allowance		(317,412)			(285,556)
Deferred tax liabilities:
Deferred rent		(72)			(237)
Net deferred tax assets	$	—		$	—



Reconciliation Of Unrecognized Tax Benefit Accounts



Balance as of December 31, 2013	$	11,634
Increase in balance related to tax positions taken in prior year		2,959
Increase in balance related to tax positions taken during current year		2,359
Balance as of December 31, 2014		16,952
Decrease in balance related to tax positions taken in prior year		(44)
Increase in balance related to tax positions taken during current year		1,827
Balance as of December 31, 2015		18,735
Decrease in balance related to tax positions taken in prior year		(3,892)
Increase in balance related to tax positions taken during current year		1,942
Balance as of December 31, 2016	$	16,785



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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32537-109319

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- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32687-109319

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Tabular disclosure of the change in unrecognized tax benefits.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 55
-Paragraph 217
-URI http://asc.fasb.org/extlink&oid=75116239&loc=d3e36027-109320

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-Name Accounting Standards Codification
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-Paragraph 15A
-URI http://asc.fasb.org/extlink&oid=65882285&loc=SL6600010-109319

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