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Consolidated Statements of Stockholders' Equity - USD ($)
shares in Thousands, $ in Thousands
Common Stock [Member]
Additional Paid-in Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Total
Balance at Dec. 31, 2013 $ 66 $ 684,413 $ 14 $ (615,313) $ 69,180
Balance, shares at Dec. 31, 2013 66,275        
Net loss       (66,160) (66,160)
Other comprehensive loss     (5)   (5)
Issuance of common stock in conjunction with equity plans $ 2 3,966     3,968
Issuance of common stock in conjunction with equity plans, shares 1,901        
Issuance of common stock in conjunction with "at-the-market" offering, net of issuance costs $ 6 38,017     38,023
Issuance of common stock in conjunction with "at-the-market" offering, net of issuance costs, shares 5,751        
Stock-based compensation expense   9,943     9,943
Balance at Dec. 31, 2014 $ 74 736,339 9 (681,473) 54,949
Balance, shares at Dec. 31, 2014 73,927        
Net loss       (31,696) (31,696)
Other comprehensive loss     (16)   (16)
Issuance of common stock in conjunction with equity plans $ 2 7,361     7,363
Issuance of common stock in conjunction with equity plans, shares 1,981        
Issuance of common stock in conjunction with "at-the-market" offering, net of issuance costs $ 4 29,096     29,100
Issuance of common stock in conjunction with "at-the-market" offering, net of issuance costs, shares 4,075        
Stock-based compensation expense   13,840     13,840
Balance at Dec. 31, 2015 $ 80 786,636 (7) (713,169) $ 73,540
Balance, shares at Dec. 31, 2015 79,983       79,983
Net loss       (74,375) $ (74,375)
Other comprehensive loss     12   12
Issuance of common stock in conjunction with equity plans $ 2 7,727     7,729
Issuance of common stock in conjunction with equity plans, shares 2,004        
Issuance of common stock in conjunction with "at-the-market" offering, net of issuance costs $ 7 58,193     58,200
Issuance of common stock in conjunction with "at-the-market" offering, net of issuance costs, shares 6,526        
Issuance of common stock from exercise of warrant $ 4 (4)      
Issuance of common stock from exercise of warrant, shares 4,164        
Stock-based compensation expense   19,562     19,562
Balance at Dec. 31, 2016 $ 93 $ 872,114 $ 5 $ (787,544) $ 84,668
Balance, shares at Dec. 31, 2016 92,677       92,677