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Unaudited Selected Quarterly Financial Data (Details) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Quarterly Financial Information [Line Items]                      
Total revenue $ 25,722 $ 25,118 $ 20,747 $ 19,127 $ 36,281 $ 13,917 $ 24,939 $ 17,645 $ 90,714 $ 92,782 $ 60,594
Total gross profit 11,374 12,638 10,644 9,504 26,466 6,551 14,506 5,927 44,160 53,450 23,402
Total operating expenses 29,248 29,373 28,714 28,069 27,528 3,937 25,864 25,255 115,404 82,584 86,256
Income (loss) from operations (17,874) (16,735) (18,070) (18,565) (1,062) 2,614 (11,358) (19,328) (71,244) (29,134) (62,854)
Net income (loss) $ (19,030) $ (17,494) $ (18,499) $ (19,352) $ (1,409) $ 1,821 $ (11,935) $ (20,173) $ (74,375) $ (31,696) $ (66,160)
Basic and diluted net loss per share $ (0.21) $ (0.19) $ (0.21) $ (0.23)              
Weighted average shares used in computation of basic and diluted net loss per share 92,660 92,110 88,148 83,604         89,148 75,614 70,475
Net income (loss) per share, basic         $ (0.02) $ 0.02 $ (0.16) $ (0.27)      
Net income (loss) per share, diluted         $ (0.02) $ 0.02 $ (0.16) $ (0.27)      
Weighted average number of shares used in computing basic net income (loss) per share         78,327 75,205 74,733 74,149      
Weighted average number of shares used in computing diluted net income (loss) per share         78,327 80,479 74,733 74,149      
Gain on lease amendments                   $ 23,043  
Roche Agreement [Member]                      
Quarterly Financial Information [Line Items]                      
Basic and diluted net loss per share                   $ (0.10)  
Deferred revenue, revenue recognized $ 1,300       $ 20,000   $ 10,000        
Lease Amendment Agreement [Member]                      
Quarterly Financial Information [Line Items]                      
Gain on lease amendments           $ 23,000