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Consolidated Statements Of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities      
Net income (loss) $ (74,375) $ (31,696) $ (66,160)
Adjustments to reconcile net loss to net cash used in operating activities      
Depreciation and amortization 3,875 3,677 4,221
Amortization of debt discount and financing costs 1,158 957 793
Stock-based compensation 19,562 13,840 9,943
Non-cash portion of gain on lease amendments   (3,043)  
Other items (147) (230) 507
Changes in assets and liabilities      
Accounts receivable (6,176) (1,738) (660)
Inventory (6,151) (2,466) (1,285)
Prepaid expenses and other assets (202) (17,889) (224)
Accounts payable 3,402 (716) 3,891
Accrued expenses 1,053 5,732 3,536
Deferred service revenue 469 708 2,686
Deferred contractual revenue (12,134) (14,386) (6,784)
Other liabilities 1,737 (639) (1,932)
Net cash used in operating activities (67,929) (47,889) (51,468)
Cash flows from investing activities      
Purchase of property and equipment (8,207) (3,009) (1,609)
Proceeds from disposal of property and equipment 10 36  
Long-term restricted cash   (4,500)  
Purchase of investments (95,848) (84,579) (126,413)
Sales of investments 23,285 8,317  
Maturities of investments 65,896 92,341 147,586
Net cash provided by (used in) investing activities (14,864) 8,606 19,564
Cash flows from financing activities      
Proceeds from issuance of common stock from equity plans 7,729 7,363 3,968
Proceeds from issuance of common stock from "at-the-market" offering, net of issuance costs 58,200 29,100 38,023
Net cash provided by financing activities 65,929 36,463 41,991
Net increase (decrease) in cash and cash equivalents (16,864) (2,820) 10,087
Cash and cash equivalents at beginning of period 33,629 36,449 26,362
Cash and cash equivalents at end of period 16,765 33,629 36,449
Supplemental disclosure of cash flow information      
Interest paid 1,799 1,794 $ 1,794
Supplemental disclosure of non-cash investing and financing activities      
Inventory transferred to property and equipment $ 1,282 $ 2,846