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Condensed Consolidated Statements Of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Cash flows from operating activities    
Net loss $ (23,867) $ (19,352)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation 2,850 848
Amortization of debt discount and financing costs 319 268
Stock-based compensation 4,984 4,581
Other items (145) 74
Changes in assets and liabilities    
Accounts receivable 980 (2,865)
Inventory (149) (2,119)
Prepaid expenses and other assets 3,377 4,709
Accounts payable (89) (39)
Accrued expenses (4,763) (3,350)
Deferred service revenue (260) (705)
Deferred contractual revenue   (3,596)
Other liabilities 92 1,279
Net cash used in operating activities (16,671) (20,267)
Cash flows from investing activities    
Purchase of property and equipment (2,668) (457)
Disposal of property and equipment   111
Purchase of investments (10,419) (43,383)
Sales of investments 3,662 4,949
Maturities of investments 34,905 15,539
Net cash provided by (used in) investing activities 25,480 (23,241)
Cash flows from financing activities    
Proceeds from issuance of common stock from equity plans 3,408 3,423
Proceeds from issuance of common stock from at-the-market equity offering, net of issuance costs   26,536
Net cash provided by financing activities 3,408 29,959
Net increase (decrease) in cash and cash equivalents 12,217 (13,549)
Cash and cash equivalents at beginning of period 16,765 33,629
Cash and cash equivalents at end of period 28,982 20,080
Supplemental disclosure of non-cash investing and financing activities    
Changes in unpaid property and equipment 5,356 $ 24
Changes in deposits for property and equipment paid in prior period 9,694  
Property and equipment paid by landlord $ 12,600