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Contractual Revenue (Details) - Roche Agreement [Member] - USD ($) | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Sep. 30, 2013 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2014 | Sep. 30, 2014 | Jun. 30, 2014 | Mar. 31, 2014 | Dec. 31, 2013 | Sep. 30, 2017 | Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-refundable upfront payment | $ 35,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amortization |  |  | $ 3,600,000 | $ 3,600,000 | $ 3,600,000 | $ 3,600,000 | $ 3,600,000 | $ 3,600,000 | $ 3,600,000 | $ 1,700,000 | $ 1,700,000 | $ 1,700,000 | $ 1,700,000 | $ 1,700,000 |  |
Deferred revenue |  |  | $ 1,300,000 |  |  |  |  |  |  |  |  |  |  |  | $ 0 |
Collaborative arrangement expiration |  |  |  |  |  |  |  |  |  |  |  |  |  |  | Feb. 01, 2017 |
Deferred revenue, revenue recognized |  | $ 1,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum potential for additional payments to be recognized upon the achievement of certain development milestones | $ 40,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
First Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, revenue recognized |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000,000
Second Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, revenue recognized |  |  |  |  |  |  |  | $ 10,000,000 |  |  |  |  |  |  |  |
Third (Final) Milestone [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred revenue, revenue recognized |  |  |  |  |  | $ 20,000,000 |  |  |  |  |  |  |  |  |  |

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- Definition Amount of deferred revenue as of balance sheet date. Deferred revenue represents collections of cash or other assets related to a revenue producing activity for which revenue has not yet been recognized. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 13.A.3) -URI http://asc.fasb.org/extlink&oid=65893310&loc=d3e214044-122780 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 605 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 13.A.4(a).Q1) -URI http://asc.fasb.org/extlink&oid=65893310&loc=d3e214044-122780 + Details
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