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Condensed Consolidated Statements Of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Cash flows from operating activities    
Net loss $ (71,427) $ (55,345)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation 6,632 2,822
Amortization of debt discount and financing costs 931 846
(Gain) Loss from derivative 640 (382)
Stock-based compensation 14,962 14,726
Other items 36 112
Changes in assets and liabilities    
Accounts receivable 2,524 (6,516)
Inventory (4,027) (7,079)
Prepaid expenses and other assets 7,361 3,024
Accounts payable 432 2,402
Accrued expenses (6,001) 931
Deferred service revenue (1,202) (502)
Deferred contractual revenue   (10,787)
Other liabilities 1,821 720
Net cash used in operating activities (47,318) (55,028)
Cash flows from investing activities    
Purchase of property and equipment (9,373) (5,556)
Disposal of property and equipment 2 10
Purchase of investments (74,591) (82,028)
Sales of investments 3,662 19,830
Maturities of investments 68,071 46,208
Net cash used in investing activities (12,229) (21,536)
Cash flows from financing activities    
Proceeds from issuance of common stock from equity plans 8,818 7,529
Notes payable principal payoff (4,500)  
Proceeds from issuance of common stock from at-the-market equity offering, net of issuance costs 11,865 58,200
Proceeds from issuance of common stock from underwritten public equity offering, net of issuance costs 52,530  
Net cash provided by financing activities 68,713 65,729
Net increase (decrease) in cash and cash equivalents 9,166 (10,835)
Cash and cash equivalents at beginning of period 16,765 33,629
Cash and cash equivalents at end of period 25,931 22,794
Supplemental disclosure of non-cash investing and financing activities    
Changes in deposits for property and equipment paid in prior period 9,694  
Property and equipment paid by landlord 12,600  
Changes in unpaid property and equipment 846 1,160
Property and equipment returned to landlord 1,854  
Inventory transferred to property and equipment $ 1,460 $ 1,561