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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Taxes [Abstract]

Reconciliation Of Federal Income Tax Rate



	Years ended December 31,
	2017			2016			2014
Statutory tax rate	35.0	%		35.0	%		35.0	%
State tax rate, net of federal benefit	8.6			5.4			(3.5)
Stock-based compensation	(1.9)			(1.6)			(4.0)
R&D credit	3.6			5.0			11.0
Tax reform	(123.3)			-			-
Other	0.3			(0.9)			(0.6)
Change in valuation allowance	77.7			(42.9)			(37.9)
Effective income tax rate	0.0	%		0.0	%		0.0	%



Reconciliation Of Deferred Tax Assets And Liabilities



	December 31,
Deferred tax assets:	2017			2016
Net operating loss carryforwards	$	194,440		$	264,183
Research and development credits		39,145			32,043
Accruals and reserves		14,480			20,088
Depreciation		—			1,170
Deferred rent		3,360			—
Total deferred tax assets		251,425			317,484
Less: Valuation allowance		(249,202)			(317,412)
Deferred tax liabilities:
Depreciation		(2,223)			—
Deferred rent					(72)
Net deferred tax assets	$	—		$	—



Reconciliation Of Unrecognized Tax Benefit Accounts



Balance as of December 31, 2014	$	16,952
Decrease in balance related to tax positions taken in prior year		(44)
Increase in balance related to tax positions taken during current year		1,827
Balance as of December 31, 2015		18,735
Decrease in balance related to tax positions taken in prior year		(3,892)
Increase in balance related to tax positions taken during current year		1,942
Balance as of December 31, 2016		16,785
Decrease in balance related to tax positions taken in prior year		—
Increase in balance related to tax positions taken during current year		2,001
Balance as of December 31, 2017	$	18,786



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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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Tabular disclosure of the change in unrecognized tax benefits.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 55
-Paragraph 217
-URI http://asc.fasb.org/extlink&oid=96868398&loc=d3e36027-109320

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-Name Accounting Standards Codification
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