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Summary of Significant Accounting Policies (Tables)

6 Months Ended

Jun. 30, 2018

Summary of Significant Accounting Policies [Abstract]

Summary of Assets and Liabilities Measured at Fair Value on a Recurring Basis



	June 30, 2018								December 31, 2017
(in thousands)	Level 1		Level 2		Level 3		Total		Level 1		Level 2		Level 3		Total
Assets
Cash and cash equivalents:
Cash and money market funds	$	16,438	$	—	$	—	$	16,438	$	14,858	$	—	$	—	$	14,858
Commercial paper		—		6,620		—		6,620		—		1,649		—		1,649
Total cash and cash equivalents		16,438		6,620		—		23,058		14,858		1,649		—		16,507
Investments:
Commercial paper		—		22,062		—		22,062		—		20,394		—		20,394
Corporate debt securities		—		4,369		—		4,369		—		9,034		—		9,034
US government & agency securities		—		14,002		—		14,002		—		16,937		—		16,937
Total investments		—		40,433		—		40,433		—		46,365		—		46,365
Long-term restricted cash:
Cash		4,500		—		—		4,500		4,500		—		—		4,500
Total assets measured at fair value	$	20,938	$	47,053	$	—	$	67,991	$	19,358	$	48,014	$	—	$	67,372

Liabilities
Financing derivative	$	—	$	—	$	40	$	40	$	—	$	—	$	183	$	183
Total liabilities measured at fair value	$	—	$	—	$	40	$	40	$	—	$	—	$	183	$	183

Estimated Fair Value and Carrying Value of Notes



	June 30, 2018				December 31, 2017
	Fair Value		Carrying Value		Fair Value		Carrying Value
Notes payable	$	15,939	$	14,121	$	15,664	$	13,635

Anti-dilutive Excluded from Computation of Diluted Net Loss per Share



	Six Months Ended June 30,
(in thousands)	2018	2017
Options to purchase common stock	28,601	25,592
RSUs with time-based vesting	355	—
RSUs with performance-based vesting	652	—

Schedule of Cumulative Effect on Consolidated Balance Sheet for Adoption of ASC 606


Balance Sheet	Balance at December 31, 2017		Adjustments Due to ASC 606		Balance at January 1, 2018
Assets
Prepaid expenses and other current assets	$	2,249	$	189	$	2,438
Liabilities and Stockholders' Equity
Accumulated deficit		(879,733)		189		(879,544)

Schedule of Impact of Revenue Standards Adoption on Financial Statements


	For the three-month period ended June 30, 2018						For the six-month period ended June 30, 2018
Statement of Operations and Comprehensive Loss	As Reported		Balances Without Adoption of ASC606		Effect of Change Higher/(Lower)		As Reported		Balances Without Adoption of ASC606		Effect of Change Higher/(Lower)
Operating Expense:
Sales, general and administrative	$	14,943	$	14,963	$	(20)	$	29,877	$	29,912	$	(35)


	As of June 30, 2018
Balance Sheet	As Reported		Balances Without Adoption of ASC606		Effect of Change Higher/(Lower)
Assets
Prepaid expenses and other current assets	$	2,035	$	1,812	$	223
Liabilities and Stockholders' Equity
Accumulated deficit	$	(926,263)	$	(926,040)	$	223


	For the six-month period ended June 30, 2018
Statement of Cash Flows	As Reported		Balances Without Adoption of ASC606		Effect of Change Higher/(Lower)
Cash Flows from Operating Activities
Net loss	$	(46,719)	$	(46,754)	$	35
Adjustments to reconcile net loss to net cash used in operating activities
Prepaid expenses and other current assets	$	337	$	302	$	35

Summary of Revenue by Category


	Three-month periods ended June 30,				Six-month periods ended June 30,
(in thousands)	2018		2017 (1)		2018		2017 (1)
Instrument revenue	$	8,525	$	7,119	$	15,669	$	19,752
Consumable revenue		9,960		9,429		19,098		18,090
Product revenue		18,485		16,548		34,767		37,842
Service and other revenue		3,093		3,525		6,173		7,146
Total revenue	$	21,578	$	20,073	$	40,940	$	44,988

(1)

As noted above, prior period amounts have not been adjusted under the modified retrospective method.

Schedule of Revenue by Geographic Location


	Three-month periods ended June 30,				Six-month periods ended June 30,
	2018		2017 (1)		2018		2017 (1)
North America	$	9,204	$	10,227	$	17,015	$	21,012
Europe (including the Middle East and Africa)		3,687		2,909		7,700		7,233
Asia Pacific		8,687		6,937		16,225		16,743
Total	$	21,578	$	20,073	$	40,940	$	44,988

(1)

As noted above, prior period amounts have not been adjusted under the modified retrospective method.

- Definition

Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.

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